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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ultrasound+Med+Biol 2015 ; 41 (5): 1372-85 Nephropedia Template TP
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INVESTIGATION INTO THE MECHANISMS OF TISSUE ATOMIZATION BY HIGH INTENSITY FOCUSED ULTRASOUND #MMPMID25662182
Simon JC; Sapozhnikov OA; Wang YN; Khokhlova VA; Crum LA; Bailey MR
Ultrasound Med Biol 2015[May]; 41 (5): 1372-85 PMID25662182show ga
Ultrasonic atomization, or the emission of a fog of droplets, was recently proposed to explain tissue fractionation in boiling histotripsy. However, even though liquid atomization has been studied extensively, the mechanisms of tissue atomization remain unclear. In this paper, high-speed photography and overpressure were used to evaluate the role of bubbles in tissue atomization. As the static pressure increased, the degree of fractionation decreased, and the ex vivo tissue became thermally denatured. The effect of surface wetness on atomization was also evaluated in vivo and in tissue-mimicking gels where surface wetness was found to enhance atomization by forming surface instabilities that augment cavitation. In addition, experimental results indicated that wetting collagenous tissues, such as the liver capsule, allowed atomization to breach such barriers. These results highlight the importance of bubbles and surface instabilities in atomization and could be used to enhance boiling histotripsy for transition to clinical use.