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10.1016/j.mvr.2010.03.007 http://scihub22266oqcxt.onion/10.1016/j.mvr.2010.03.007 C4398341!4398341 !20303995     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20303995 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microvasc+Res 2010 ; 80 (1 ): 89-98 Nephropedia Template TP {{tp|p=20303995 |t=2010. Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography |pdf=|usr=}}{{20303995 }} gab.com Text Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography JO: Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=20303995 #FOAvip OBJECTIVE: In order to perform effective translational research for cancer therapy, we need to employ pre-clinical models which reflect the clinical situation. The purpose of this study was to quantitatively compare the vascular architecture of human colorectal cancer and experimental tumour models to determine the suitability of animal models for vascular studies and antivascular therapy. METHODS: In this study we investigated the three-dimensional properties of colonic tumour vasculature in both human clinical tissues (normal mucosa control [n=20], carcinoma [n=20] and adenoma [n=6]) and murine colorectal xenografts (LS147T [n=6] and SW1222 [n=6]). Scanning Electron Microscope Stereoimaging (SEM) and X-ray Micro-Computed Tomography (Micro-CT) methods were employed for 3D analyses of the vascular corrosion casts from these tissues. RESULTS: Morphological measurements showed that there were significant differences in the underlying morphology in the different tissues. Of the studied xenografts, LS147T is more consistently similar to the vascular architecture of the human carcinoma than SW1222. The only reversal of this is for the inter-vessel distance. CONCLUSION: While SEM stereoimaging provided better surface detailed resolution of the corrosion casts, it was complimented by the fully 3D micro-CT method. Comparison made between the xenografts and clinical tumours showed that the LS147T xenografts shared many similarities with the clinical tumour vasculature. This study provides insight into how to select the most suitable pre-clinical models for translational studies of clinical cancer therapy. Twit Text FOAVip Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography ????Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=20303995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20303995 #FOAvip English Wikipedia <ref>{{Cite pmid|20303995 }}</ref> Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography #MMPMID20303995 Folarin AA ; Konerding MA ; Timonen J ; Nagl S ; Pedley RB Microvasc Res 2010[Jul]; 80 (1 ): 89-98 PMID20303995 show ga OBJECTIVE: In order to perform effective translational research for cancer therapy, we need to employ pre-clinical models which reflect the clinical situation. The purpose of this study was to quantitatively compare the vascular architecture of human colorectal cancer and experimental tumour models to determine the suitability of animal models for vascular studies and antivascular therapy. METHODS: In this study we investigated the three-dimensional properties of colonic tumour vasculature in both human clinical tissues (normal mucosa control [n=20], carcinoma [n=20] and adenoma [n=6]) and murine colorectal xenografts (LS147T [n=6] and SW1222 [n=6]). Scanning Electron Microscope Stereoimaging (SEM) and X-ray Micro-Computed Tomography (Micro-CT) methods were employed for 3D analyses of the vascular corrosion casts from these tissues. RESULTS: Morphological measurements showed that there were significant differences in the underlying morphology in the different tissues. Of the studied xenografts, LS147T is more consistently similar to the vascular architecture of the human carcinoma than SW1222. The only reversal of this is for the inter-vessel distance. CONCLUSION: While SEM stereoimaging provided better surface detailed resolution of the corrosion casts, it was complimented by the fully 3D micro-CT method. Comparison made between the xenografts and clinical tumours showed that the LS147T xenografts shared many similarities with the clinical tumour vasculature. This study provides insight into how to select the most suitable pre-clinical models for translational studies of clinical cancer therapy. |*Corrosion Casting [MESH] |Adenoma/blood supply/pathology [MESH] |Animals [MESH] |Carcinoma/blood supply/pathology [MESH] |Cell Line, Tumor [MESH] |Colon/anatomy & histology/blood supply/pathology [MESH] |Colorectal Neoplasms/blood supply/pathology [MESH] |Female [MESH] |Humans [MESH] |Imaging, Three-Dimensional/*methods [MESH] |Intestinal Mucosa/anatomy & histology/blood supply [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Microscopy, Electron, Scanning/methods [MESH] |Microvessels/*pathology [MESH] |Neoplasms/*blood supply/pathology [MESH] |Transplantation, Heterologous/pathology [MESH]Three-dimensional analysis of tumour vascular corrosion casts using st(epmc).pdf DeepDyve Pubget Overpricing