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10.1186/s12886-015-0023-1 http://scihub22266oqcxt.onion/10.1186/s12886-015-0023-1 C4397858!4397858!25881294     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Ophthalmol 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=25881294|t=2015. Investigation of novel autoantibodies in Sjogren?s syndrome utilizing Sera from the Sjogren?s international collaborative clinical alliance cohort |pdf=|usr=}}{{25881294}} gab.com Text Investigation of novel autoantibodies in Sjogren s syndrome utilizing Sera from the Sjogren s international collaborative clinical alliance cohort JO: BMC Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=25881294 #FOAvip Background: Sjogren?s syndrome (SS) is a chronic autoimmune disease mainly affecting salivary and lacrimal glands. Current diagnostic criteria for SS utilize anti-Ro and anti-La as serological markers. Animal models for SS have identified novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel antibodies are seen in the animals at an earlier stage of SS than anti-Ro and anti-La. The current studies were designed to evaluate these novel autoantibodies in the sera of well-characterized patients with dry eyes and dry mouth and lip biopsies from the Sjogren?s International Collaborative Clinical Alliance (SICCA) to determine if they indeed identify SS with less severe disease than patients expressing anti-Ro and anti-La. Methods: Sera were obtained from SICCA registry in patients for whom lymphocytic foci per 4 mm2 on the lip biopsies was either 0 (F = 0), <1 (F <1) or > 3 (F >3). ELISA assays were utilized to evaluate these sera for anti-Ro, anti-La, anti-SP1, anti-CA6, and anti-PSP. Results: In patients with dry eyes and dry mouth but F?=?0, increased expression of anti- CA6 was noted compared to the F <1 group (p?=?.032) or the F?>?3 group (p?=?.006). Neither anti-PSP nor anti-SP1 reached statistical significance because of the small numbers in the F0 group, although there was a trend for their expression to be higher in the F0 group. On the other hand, the expression of anti-Ro was significantly reduced in the F0 group compared to the F <1 (p?=?.0021) and F?>?3 (p?=?.0003) groups. The reduced expression of anti-La in the F0 group compared to the F <1 and F?>?3 groups did not quite reach statistical significance. Conclusions: Anti-Ro and anti-La identify patients with SS and more severe disease than anti-SP1, anti-CA6, and anti-PSP. More studies are needed to identify the timing in the course of SS when these different autoantibodies are expressed and/or whether they are expressed in patients with different clinical manifestations. Twit Text FOAVip Investigation of novel autoantibodies in Sjogren s syndrome utilizing Sera from the Sjogren s international collaborative clinical alliance cohort ????BMC Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=25881294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25881294 #FOAvip English Wikipedia <ref>{{Cite pmid|25881294}}</ref> Investigation of novel autoantibodies in Sjogren?s syndrome utilizing Sera from the Sjogren?s international collaborative clinical alliance cohort #MMPMID25881294 Suresh L; Malyavantham K; Shen L; Ambrus JL BMC Ophthalmol 2015[]; 15 (ä): ä PMID25881294show ga Background: Sjogren?s syndrome (SS) is a chronic autoimmune disease mainly affecting salivary and lacrimal glands. Current diagnostic criteria for SS utilize anti-Ro and anti-La as serological markers. Animal models for SS have identified novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel antibodies are seen in the animals at an earlier stage of SS than anti-Ro and anti-La. The current studies were designed to evaluate these novel autoantibodies in the sera of well-characterized patients with dry eyes and dry mouth and lip biopsies from the Sjogren?s International Collaborative Clinical Alliance (SICCA) to determine if they indeed identify SS with less severe disease than patients expressing anti-Ro and anti-La. Methods: Sera were obtained from SICCA registry in patients for whom lymphocytic foci per 4 mm2 on the lip biopsies was either 0 (F = 0), <1 (F <1) or > 3 (F >3). ELISA assays were utilized to evaluate these sera for anti-Ro, anti-La, anti-SP1, anti-CA6, and anti-PSP. Results: In patients with dry eyes and dry mouth but F?=?0, increased expression of anti- CA6 was noted compared to the F <1 group (p?=?.032) or the F?>?3 group (p?=?.006). Neither anti-PSP nor anti-SP1 reached statistical significance because of the small numbers in the F0 group, although there was a trend for their expression to be higher in the F0 group. On the other hand, the expression of anti-Ro was significantly reduced in the F0 group compared to the F <1 (p?=?.0021) and F?>?3 (p?=?.0003) groups. The reduced expression of anti-La in the F0 group compared to the F <1 and F?>?3 groups did not quite reach statistical significance. Conclusions: Anti-Ro and anti-La identify patients with SS and more severe disease than anti-SP1, anti-CA6, and anti-PSP. More studies are needed to identify the timing in the course of SS when these different autoantibodies are expressed and/or whether they are expressed in patients with different clinical manifestations. äInvestigation of novel autoantibodies in Sjogren?s syndrome utilizing (epmc).pdf DeepDyve Pubget Overpricing