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Investigation of novel autoantibodies in Sjogren s syndrome utilizing Sera from
the Sjogren s international collaborative clinical alliance cohort
#MMPMID25881294
Suresh L
; Malyavantham K
; Shen L
; Ambrus JL Jr
BMC Ophthalmol
2015[Apr]; 15
(?): 38
PMID25881294
show ga
BACKGROUND: Sjogren's syndrome (SS) is a chronic autoimmune disease mainly
affecting salivary and lacrimal glands. Current diagnostic criteria for SS
utilize anti-Ro and anti-La as serological markers. Animal models for SS have
identified novel autoantibodies, anti-salivary gland protein 1 (SP1),
anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel
antibodies are seen in the animals at an earlier stage of SS than anti-Ro and
anti-La. The current studies were designed to evaluate these novel autoantibodies
in the sera of well-characterized patients with dry eyes and dry mouth and lip
biopsies from the Sjogren's International Collaborative Clinical Alliance (SICCA)
to determine if they indeed identify SS with less severe disease than patients
expressing anti-Ro and anti-La. METHODS: Sera were obtained from SICCA registry
in patients for whom lymphocytic foci per 4 mm(2) on the lip biopsies was either
0 (F = 0), <1 (F <1) or > 3 (F >3). ELISA assays were utilized to evaluate these
sera for anti-Ro, anti-La, anti-SP1, anti-CA6, and anti-PSP. RESULTS: In patients
with dry eyes and dry mouth but F = 0, increased expression of anti- CA6 was
noted compared to the F <1 group (p =?.032) or the F > 3 group (p =?.006).
Neither anti-PSP nor anti-SP1 reached statistical significance because of the
small numbers in the F0 group, although there was a trend for their expression to
be higher in the F0 group. On the other hand, the expression of anti-Ro was
significantly reduced in the F0 group compared to the F <1 (p =?.0021) and F > 3
(p =?.0003) groups. The reduced expression of anti-La in the F0 group compared to
the F <1 and F > 3 groups did not quite reach statistical significance.
CONCLUSIONS: Anti-Ro and anti-La identify patients with SS and more severe
disease than anti-SP1, anti-CA6, and anti-PSP. More studies are needed to
identify the timing in the course of SS when these different autoantibodies are
expressed and/or whether they are expressed in patients with different clinical
manifestations.
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