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10.1038/ncomms7380 http://scihub22266oqcxt.onion/10.1038/ncomms7380 C4397653!4397653!25871009     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 6380 Nephropedia Template TP {{tp|p=25871009|t=2015. Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development |pdf=|usr=}}{{25871009}} gab.com Text Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25871009 #FOAvip Uncontrolled canonical Wnt signaling supports colon epithelial tumor expansion and malignant transformation. Understanding the regulatory mechanisms involved is crucial for elucidating the pathogenesis of and will provide new therapeutic targets for colon cancer. Epsins are ubiquitin-binding adaptor proteins upregulated in several human cancers; however, epsins? involvement in colon cancer is unknown. Here we show that loss of intestinal epithelial epsins protects against colon cancer by significantly reducing the stability of the crucial Wnt signaling effector, dishevelled (Dvl2), and impairing Wnt signaling. Consistently, epsins and Dvl2 are correspondingly upregulated in colon cancer. Mechanistically, epsin binds Dvl2 via its epsin N-terminal homology domain and ubiquitin-interacting motifs and prohibits Dvl2 polyubiquitination and degradation. Our findings reveal an unconventional role for epsins in stabilizing Dvl2 and potentiating Wnt signaling in colon cancer cells to ensure robust colon cancer progression. Epsins? pro-carcinogenic role suggests they are potential therapeutic targets to combat colon cancer. Twit Text FOAVip Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25871009 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25871009 #FOAvip English Wikipedia <ref>{{Cite pmid|25871009}}</ref> Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development #MMPMID25871009 Chang B; Tessneer KL; McManus J; Liu X; Hahn S; Pasula S; Wu H; Song H; Chen Y; Cai X; Dong Y; Brophy ML; Rahman R; Ma JX; Xia L; Chen H Nat Commun 2015[]; 6 (ä): 6380 PMID25871009show ga Uncontrolled canonical Wnt signaling supports colon epithelial tumor expansion and malignant transformation. Understanding the regulatory mechanisms involved is crucial for elucidating the pathogenesis of and will provide new therapeutic targets for colon cancer. Epsins are ubiquitin-binding adaptor proteins upregulated in several human cancers; however, epsins? involvement in colon cancer is unknown. Here we show that loss of intestinal epithelial epsins protects against colon cancer by significantly reducing the stability of the crucial Wnt signaling effector, dishevelled (Dvl2), and impairing Wnt signaling. Consistently, epsins and Dvl2 are correspondingly upregulated in colon cancer. Mechanistically, epsin binds Dvl2 via its epsin N-terminal homology domain and ubiquitin-interacting motifs and prohibits Dvl2 polyubiquitination and degradation. Our findings reveal an unconventional role for epsins in stabilizing Dvl2 and potentiating Wnt signaling in colon cancer cells to ensure robust colon cancer progression. Epsins? pro-carcinogenic role suggests they are potential therapeutic targets to combat colon cancer. äEpsin is required for Dishevelled stability and Wnt signaling activati(epmc).pdf DeepDyve Pubget Overpricing