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10.1177/1759091415578711 http://scihub22266oqcxt.onion/10.1177/1759091415578711 C4397212!4397212!25873304     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ASN+Neuro 2015 ; 7 (2): ä Nephropedia Template TP {{tp|p=25873304|t=2015. Cystathionine ?-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury |pdf=|usr=}}{{25873304}} gab.com Text Cystathionine -Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury JO: ASN Neuro http://www.kidney.de/pget.php?&tw=1&pmid=25873304 #FOAvip Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine ?-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y cells were transfected to overexpress CBS, these cells were able to synthesize H2S when exposed to high levels of enzyme substrates but not substrate concentrations that may reflect normal physiological conditions. At the same time, these cells demonstrated exacerbated cell death when subjected to oxygen and glucose deprivation (OGD) together with high substrate concentrations, indicating that H2S production has a detrimental effect on cell survival. This effect could be abolished by CBS inhibition. The same effect was observed with primary astrocytes exposed to OGD and high substrates or sodium hydrosulfide. In addition, CBS was upregulated and activated by truncation in primary astrocytes subjected to OGD. When rats were subjected to permanent middle cerebral artery occlusion, CBS activation was also observed. These results imply that in acute ischemic conditions, CBS is upregulated and activated by truncation causing an increased production of H2S, which exacerbate the ischemic injuries. Therefore, CBS inhibition may be a viable approach to stroke treatment. Twit Text FOAVip Cystathionine -Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury ????ASN Neuro http://www.kidney.de/pget.php?&tw=1&pmid=25873304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25873304 #FOAvip English Wikipedia <ref>{{Cite pmid|25873304}}</ref> Cystathionine ?-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury #MMPMID25873304 Chan SJ; Chai C; Lim TW; Yamamoto M; Lo EH; Lai MKP; Wong PTH ASN Neuro 2015[Mar]; 7 (2): ä PMID25873304show ga Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine ?-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y cells were transfected to overexpress CBS, these cells were able to synthesize H2S when exposed to high levels of enzyme substrates but not substrate concentrations that may reflect normal physiological conditions. At the same time, these cells demonstrated exacerbated cell death when subjected to oxygen and glucose deprivation (OGD) together with high substrate concentrations, indicating that H2S production has a detrimental effect on cell survival. This effect could be abolished by CBS inhibition. The same effect was observed with primary astrocytes exposed to OGD and high substrates or sodium hydrosulfide. In addition, CBS was upregulated and activated by truncation in primary astrocytes subjected to OGD. When rats were subjected to permanent middle cerebral artery occlusion, CBS activation was also observed. These results imply that in acute ischemic conditions, CBS is upregulated and activated by truncation causing an increased production of H2S, which exacerbate the ischemic injuries. Therefore, CBS inhibition may be a viable approach to stroke treatment. äCystathionine ?-Synthase Inhibition Is a Potential Therapeutic Approac(epmc).pdf DeepDyve Pubget Overpricing