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10.1096/fj.14-260828 http://scihub22266oqcxt.onion/10.1096/fj.14-260828 C4396615!4396615!25573755     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25573755.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FASEB+J 2015 ; 29 (4): 1551-63 Nephropedia Template TP {{tp|p=25573755|t=2015. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling |pdf=|usr=}}{{25573755}} gab.com Text Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=25573755 #FOAvip Water channel aquaporin-1 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle. Recently, AQP1 was reported to interact with ?-catenin. Here we investigated the relationship between AQP1 and Wnt signaling in in vitro and in vivo models of autosomal dominant polycystic kidney disease (PKD). AQP1 overexpression decreased ?-catenin and cyclinD1 expression, suggesting down-regulation of Wnt signaling, and coimmunoprecipitation showed AQP1 interaction with ?-catenin, glycogen synthase kinase 3?, LRP6, and Axin1. AQP1 inhibited cyst development and promoted branching in matrix-grown MDCK cells. In embryonic kidney cultures, AQP1 deletion increased cyst development by up to ?40%. Kidney size and cyst number were significantly greater in AQP1-null PKD mice than in AQP1-expressing PKD mice, with the difference mainly attributed to a greater number of proximal tubule cysts. Biochemical analysis revealed decreased ?-catenin phosphorylation and increased ?-catenin expression in AQP1-null PKD mice, suggesting enhanced Wnt signaling. These results implicate AQP1 as a novel determinant in renal cyst development that may involve inhibition of Wnt signaling by an AQP1-macromolecular signaling complex.?Wang, W., Li, F., Sun, Y., Lei, L., Zhou, H., Lei, T., Xia, Y., Verkman, A. S., Yang, B. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. Twit Text FOAVip Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=25573755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25573755 #FOAvip English Wikipedia <ref>{{Cite pmid|25573755}}</ref> Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling #MMPMID25573755 Wang W; Li F; Sun Y; Lei L; Zhou H; Lei T; Xia Y; Verkman AS; Yang B FASEB J 2015[Apr]; 29 (4): 1551-63 PMID25573755show ga Water channel aquaporin-1 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle. Recently, AQP1 was reported to interact with ?-catenin. Here we investigated the relationship between AQP1 and Wnt signaling in in vitro and in vivo models of autosomal dominant polycystic kidney disease (PKD). AQP1 overexpression decreased ?-catenin and cyclinD1 expression, suggesting down-regulation of Wnt signaling, and coimmunoprecipitation showed AQP1 interaction with ?-catenin, glycogen synthase kinase 3?, LRP6, and Axin1. AQP1 inhibited cyst development and promoted branching in matrix-grown MDCK cells. In embryonic kidney cultures, AQP1 deletion increased cyst development by up to ?40%. Kidney size and cyst number were significantly greater in AQP1-null PKD mice than in AQP1-expressing PKD mice, with the difference mainly attributed to a greater number of proximal tubule cysts. Biochemical analysis revealed decreased ?-catenin phosphorylation and increased ?-catenin expression in AQP1-null PKD mice, suggesting enhanced Wnt signaling. These results implicate AQP1 as a novel determinant in renal cyst development that may involve inhibition of Wnt signaling by an AQP1-macromolecular signaling complex.?Wang, W., Li, F., Sun, Y., Lei, L., Zhou, H., Lei, T., Xia, Y., Verkman, A. S., Yang, B. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. äAquaporin-1 retards renal cyst development in polycystic kidney diseas(epmc).pdf DeepDyve Pubget Overpricing