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10.1172/JCI75417 http://scihub22266oqcxt.onion/10.1172/JCI75417 C4396492!4396492!25751064     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (4): 1620-36 Nephropedia Template TP {{tp|p=25751064|t=2015. KIM-1?mediated phagocytosis reduces acute injury to the kidney |pdf=|usr=}}{{25751064}} gab.com Text KIM-1 mediated phagocytosis reduces acute injury to the kidney JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25751064 #FOAvip Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. Here, we determined that early in the injury process, however, KIM-1 expression is antiinflammatory due to its mediation of phagocytic processes in tubule cells. Using various models of acute kidney injury (AKI) and mice expressing mutant forms of KIM-1, we demonstrated a mucin domain?dependent protective effect of epithelial KIM-1 expression that involves downregulation of innate immunity. Deletion of the mucin domain markedly impaired KIM-1?mediated phagocytic function, resulting in increased proinflammatory cytokine production, decreased antiinflammatory growth factor secretion by proximal epithelial cells, and a subsequent increase in tissue macrophages. Mice expressing KIM-1?mucin had greater functional impairment, inflammatory responses, and mortality in response to ischemia- and cisplatin-induced AKI. Compared with primary renal proximal tubule cells isolated from KIM-1?mucin mice, those from WT mice had reduced proinflammatory cytokine secretion and impaired macrophage activation. The antiinflammatory effect of KIM-1 expression was due to the interaction of KIM-1 with p85 and subsequent PI3K-dependent downmodulation of NF-?B. Hence, KIM-1?mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. Twit Text FOAVip KIM-1 mediated phagocytosis reduces acute injury to the kidney ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25751064 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25751064 #FOAvip English Wikipedia <ref>{{Cite pmid|25751064}}</ref> KIM-1?mediated phagocytosis reduces acute injury to the kidney #MMPMID25751064 Yang L; Brooks CR; Xiao S; Sabbisetti V; Yeung MY; Hsiao LL; Ichimura T; Kuchroo V; Bonventre JV J Clin Invest 2015[Apr]; 125 (4): 1620-36 PMID25751064show ga Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. Here, we determined that early in the injury process, however, KIM-1 expression is antiinflammatory due to its mediation of phagocytic processes in tubule cells. Using various models of acute kidney injury (AKI) and mice expressing mutant forms of KIM-1, we demonstrated a mucin domain?dependent protective effect of epithelial KIM-1 expression that involves downregulation of innate immunity. Deletion of the mucin domain markedly impaired KIM-1?mediated phagocytic function, resulting in increased proinflammatory cytokine production, decreased antiinflammatory growth factor secretion by proximal epithelial cells, and a subsequent increase in tissue macrophages. Mice expressing KIM-1?mucin had greater functional impairment, inflammatory responses, and mortality in response to ischemia- and cisplatin-induced AKI. Compared with primary renal proximal tubule cells isolated from KIM-1?mucin mice, those from WT mice had reduced proinflammatory cytokine secretion and impaired macrophage activation. The antiinflammatory effect of KIM-1 expression was due to the interaction of KIM-1 with p85 and subsequent PI3K-dependent downmodulation of NF-?B. Hence, KIM-1?mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. äKIM-1?mediated phagocytosis reduces acute injury to the kidney (epmc).pdf DeepDyve Pubget Overpricing