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10.1038/leu.2014.346

http://scihub22266oqcxt.onion/10.1038/leu.2014.346
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C4396402!4396402!25486871
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suck abstract from ncbi


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pmid25486871      Leukemia 2015 ; 29 (4): 776-82
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  • A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking #MMPMID25486871
  • Ratajczak MZ
  • Leukemia 2015[Apr]; 29 (4): 776-82 PMID25486871show ga
  • This review presents a novel view and working hypothesis about the hierarchy within the adult bone marrow stem cell compartment and the still-intriguing question of whether adult bone marrow contains primitive stem cells from early embryonic development, such as cells derived from the epiblast, migrating primordial germ cells or yolk sac-derived hemangioblasts. It also presents a novel view of the mechanisms that govern stem cell mobilization and homing, with special emphasis on the role of the complement cascade as a trigger for egress of hematopoietic stem cells from bone marrow into blood as well as the emerging role of novel homing factors and priming mechanisms that support stromal-derived factor 1-mediated homing of hematopoietic stem/progenitor cells after transplantation.
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