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10.1038/ncomms7709 http://scihub22266oqcxt.onion/10.1038/ncomms7709 C4396374!4396374!25833741     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun ä ; 6 (ä): ä Nephropedia Template TP {{tp|p=25833741|t=ä. Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms |pdf=|usr=}}{{25833741}} gab.com Text Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25833741 #FOAvip In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic pattern of gene expression. Here we quantify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gradient increases over time, the activity of the pathway transcriptional effectors, Gli proteins, initially increases but later decreases. Computational analysis of the pathway suggests three mechanisms that could contribute to this adaptation: transcriptional upregulation of the inhibitory receptor Ptch1, transcriptional downregulation of Gli and the differential stability of active and inactive Gli isoforms. Consistent with this, Gli2 protein expression is downregulated during neural tube patterning and adaptation continues when the pathway is stimulated downstream of Ptch1. Moreover, the Shh-induced upregulation of Gli2 transcription prevents Gli activity levels from adapting in a different cell type, NIH3T3 fibroblasts, despite the upregulation of Ptch1. Multiple mechanisms therefore contribute to the intracellular dynamics of Shh signalling, resulting in different signalling dynamics in different cell types. Twit Text FOAVip Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25833741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25833741 #FOAvip English Wikipedia <ref>{{Cite pmid|25833741}}</ref> Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms #MMPMID25833741 Cohen M; Kicheva A; Ribeiro A; Blassberg R; Page KM; Barnes CP; Briscoe J Nat Commun ä[]; 6 (ä): ä PMID25833741show ga In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic pattern of gene expression. Here we quantify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gradient increases over time, the activity of the pathway transcriptional effectors, Gli proteins, initially increases but later decreases. Computational analysis of the pathway suggests three mechanisms that could contribute to this adaptation: transcriptional upregulation of the inhibitory receptor Ptch1, transcriptional downregulation of Gli and the differential stability of active and inactive Gli isoforms. Consistent with this, Gli2 protein expression is downregulated during neural tube patterning and adaptation continues when the pathway is stimulated downstream of Ptch1. Moreover, the Shh-induced upregulation of Gli2 transcription prevents Gli activity levels from adapting in a different cell type, NIH3T3 fibroblasts, despite the upregulation of Ptch1. Multiple mechanisms therefore contribute to the intracellular dynamics of Shh signalling, resulting in different signalling dynamics in different cell types. äPtch1 and Gli regulate Shh signalling dynamics via multiple mechanisms(epmc).pdf DeepDyve Pubget Overpricing