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10.1038/ncomms7605 http://scihub22266oqcxt.onion/10.1038/ncomms7605 C4396364!4396364!25827447     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun ä ; 6 (ä): ä Nephropedia Template TP {{tp|p=25827447|t=ä. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer |pdf=|usr=}}{{25827447}} gab.com Text Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25827447 #FOAvip Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours. We find one case of metastatic spread to the surgical bed causing local recurrence, and another case of cross-metastatic site seeding combining with dynamic remoulding of subclonal mixtures in response to therapy. By ultra-deep sequencing end-stage blood, we detect both metastatic and primary tumour clones, even years after removal of the prostate. Analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations, and additional sequencing of metastases from 19 patients demonstrates that acquisition of TP53 mutations is linked with the expansion of subclones with metastatic potential which we can detect in the blood. Twit Text FOAVip Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25827447 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25827447 #FOAvip English Wikipedia <ref>{{Cite pmid|25827447}}</ref> Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer #MMPMID25827447 Hong MK; Macintyre G; Wedge DC; Van Loo P; Patel K; Lunke S; Alexandrov LB; Sloggett C; Cmero M; Marass F; Tsui D; Mangiola S; Lonie A; Naeem H; Sapre N; Phal PM; Kurganovs N; Chin X; Kerger M; Warren AY; Neal D; Gnanapragasam V; Rosenfeld N; Pedersen JS; Ryan A; Haviv I; Costello AJ; Corcoran NM; Hovens CM Nat Commun ä[]; 6 (ä): ä PMID25827447show ga Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours. We find one case of metastatic spread to the surgical bed causing local recurrence, and another case of cross-metastatic site seeding combining with dynamic remoulding of subclonal mixtures in response to therapy. By ultra-deep sequencing end-stage blood, we detect both metastatic and primary tumour clones, even years after removal of the prostate. Analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations, and additional sequencing of metastases from 19 patients demonstrates that acquisition of TP53 mutations is linked with the expansion of subclones with metastatic potential which we can detect in the blood. äTracking the origins and drivers of subclonal metastatic expansion in (epmc).pdf DeepDyve Pubget Overpricing