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10.1038/ncomms7717 http://scihub22266oqcxt.onion/10.1038/ncomms7717 C4396363!4396363 !25848958     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25848958 &cmd=llinks): Failed to open stream: HTTP request failed! 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Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe |pdf=|usr=}}{{25848958 }} gab.com Text Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25848958 #FOAvip Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Twit Text FOAVip Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25848958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25848958 #FOAvip English Wikipedia <ref>{{Cite pmid|25848958 }}</ref> Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe #MMPMID25848958 Kay GL ; Sergeant MJ ; Zhou Z ; Chan JZ ; Millard A ; Quick J ; Szikossy I ; Pap I ; Spigelman M ; Loman NJ ; Achtman M ; Donoghue HD ; Pallen MJ Nat Commun 2015[Apr]; 6 (ä): 6717 PMID25848958 show ga Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. |Adult [MESH] |Bayes Theorem [MESH] |Coinfection/*microbiology [MESH] |DNA, Bacterial/*analysis [MESH] |Europe/epidemiology [MESH] |Female [MESH] |Genome, Bacterial/*genetics [MESH] |Genotype [MESH] |History, 18th Century [MESH] |Humans [MESH] |Hungary/epidemiology [MESH] |Male [MESH] |Metagenomics [MESH] |Middle Aged [MESH] |Molecular Epidemiology [MESH] |Mycobacterium tuberculosis/*genetics [MESH] |Phylogeny [MESH] |Tuberculosis/epidemiology/history/*microbiology [MESH]Eighteenth-century genomes show that mixed infections were common at t(epmc).pdf DeepDyve Pubget Overpricing