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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Med+Res+Methodol
2015 ; 15
(ä): 30
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The rise of multiple imputation: a review of the reporting and implementation of
the method in medical research
#MMPMID25880850
Hayati Rezvan P
; Lee KJ
; Simpson JA
BMC Med Res Methodol
2015[Apr]; 15
(ä): 30
PMID25880850
show ga
BACKGROUND: Missing data are common in medical research, which can lead to a loss
in statistical power and potentially biased results if not handled appropriately.
Multiple imputation (MI) is a statistical method, widely adopted in practice, for
dealing with missing data. Many academic journals now emphasise the importance of
reporting information regarding missing data and proposed guidelines for
documenting the application of MI have been published. This review evaluated the
reporting of missing data, the application of MI including the details provided
regarding the imputation model, and the frequency of sensitivity analyses within
the MI framework in medical research articles. METHODS: A systematic review of
articles published in the Lancet and New England Journal of Medicine between
January 2008 and December 2013 in which MI was implemented was carried out.
RESULTS: We identified 103 papers that used MI, with the number of papers
increasing from 11 in 2008 to 26 in 2013. Nearly half of the papers specified the
proportion of complete cases or the proportion with missing data by each
variable. In the majority of the articles (86%) the imputed variables were
specified. Of the 38 papers (37%) that stated the method of imputation, 20 used
chained equations, 8 used multivariate normal imputation, and 10 used alternative
methods. Very few articles (9%) detailed how they handled non-normally
distributed variables during imputation. Thirty-nine papers (38%) stated the
variables included in the imputation model. Less than half of the papers (46%)
reported the number of imputations, and only two papers compared the distribution
of imputed and observed data. Sixty-six papers presented the results from MI as a
secondary analysis. Only three articles carried out a sensitivity analysis
following MI to assess departures from the missing at random assumption, with
details of the sensitivity analyses only provided by one article. CONCLUSIONS:
This review outlined deficiencies in the documenting of missing data and the
details provided about imputation. Furthermore, only a few articles performed
sensitivity analyses following MI even though this is strongly recommended in
guidelines. Authors are encouraged to follow the available guidelines and provide
information on missing data and the imputation process.
|*Data Interpretation, Statistical
[MESH]
|Biomedical Research/methods/standards/*statistics & numerical data
[MESH]
|Biometry/methods
[MESH]
|Humans
[MESH]
|Periodicals as Topic/standards/*statistics & numerical data
[MESH]