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Hippocampal-prefrontal circuit and disrupted functional connectivity in
psychiatric and neurodegenerative disorders
#MMPMID25918722
Li M
; Long C
; Yang L
Biomed Res Int
2015[]; 2015
(?): 810548
PMID25918722
show ga
In rodents, the hippocampus has been studied extensively as part of a brain
system responsible for learning and memory, and the prefrontal cortex (PFC)
participates in numerous cognitive functions including working memory,
flexibility, decision making, and rewarding learning. The neuronal projections
from the hippocampus, either directly or indirectly, to the PFC, referred to as
the hippocampal-prefrontal cortex (Hip-PFC) circuit, play a critical role in
cognitive and emotional regulation and memory consolidation. Although in certain
psychiatric and neurodegenerative diseases, structural connectivity viewed by
imaging techniques has been consistently found to be associated with clinical
phenotype and disease severity, the focus has moved towards the investigation of
connectivity correlates of molecular pathology and coupling of oscillation.
Moreover, functional and structural connectivity measures have been emerging as
potential intermediate biomarkers for neuronal disorders. In this review, we
summarize progress on the anatomic, molecular, and electrophysiological
characters of the Hip-PFC circuit in cognition and emotion processes with an
emphasis on oscillation and functional connectivity, revealing a disrupted
Hip-PFC connectivity and electrical activity in psychiatric and neurodegenerative
disorders as a promising candidate of neural marker for neuronal disorders.
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