Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13073-015-0147-1 http://scihub22266oqcxt.onion/10.1186/s13073-015-0147-1 C4395979!4395979!25874000     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Med 2015 ; 7 (1): ä Nephropedia Template TP {{tp|p=25874000|t=2015. Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation |pdf=|usr=}}{{25874000}} gab.com Text Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation JO: Genome Med http://www.kidney.de/pget.php?&tw=1&pmid=25874000 #FOAvip Tumor heterogeneity is of growing importance in the treatment of cancers. Mutational hot spots are prime locations for determining number and proportions of low variant allele frequency (VAF) tumor subclones by next generation sequencing. Low VAF detection is complicated by poor mapping efficiency in regions with high mutation density. Our Deep-Drilling with iterative Mapping (DDiMAP) method retains variant allele patterns to aid in single nucleotide variation detection and generation of additional reference alleles, with remapping increasing coverage of highly mutated regions to capture data critical to heterogeneity analysis and enhancing sensitivity. DDiMAP outputs variant patterns with frequencies, enabling rapid phylogenetic analysis of ongoing mutation.Electronic supplementary material: The online version of this article (doi:10.1186/s13073-015-0147-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation ????Genome Med http://www.kidney.de/pget.php?&tw=1&pmid=25874000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25874000 #FOAvip English Wikipedia <ref>{{Cite pmid|25874000}}</ref> Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation #MMPMID25874000 Spence JM; Spence JP; Abumoussa A; Burack WR Genome Med 2015[]; 7 (1): ä PMID25874000show ga Tumor heterogeneity is of growing importance in the treatment of cancers. Mutational hot spots are prime locations for determining number and proportions of low variant allele frequency (VAF) tumor subclones by next generation sequencing. Low VAF detection is complicated by poor mapping efficiency in regions with high mutation density. Our Deep-Drilling with iterative Mapping (DDiMAP) method retains variant allele patterns to aid in single nucleotide variation detection and generation of additional reference alleles, with remapping increasing coverage of highly mutated regions to capture data critical to heterogeneity analysis and enhancing sensitivity. DDiMAP outputs variant patterns with frequencies, enabling rapid phylogenetic analysis of ongoing mutation.Electronic supplementary material: The online version of this article (doi:10.1186/s13073-015-0147-1) contains supplementary material, which is available to authorized users. äUltradeep analysis of tumor heterogeneity in regions of somatic hyperm(epmc).pdf DeepDyve Pubget Overpricing