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2015 ; 31
(ä): 135-41
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Epidemiological and molecular characteristics of HIV infection among money boys
and general men who have sex with men in Shanghai, China
#MMPMID25653132
Yan H
; Ding Y
; Wong FY
; Ning Z
; Zheng T
; Nehl EJ
; He N
Infect Genet Evol
2015[Apr]; 31
(ä): 135-41
PMID25653132
show ga
To examine and compare the epidemiological and molecular characteristics of HIV
infection between money boys (MBs) and general men who have sex with men (MSM) in
Shanghai, China. Using a venue-based sampling strategy, a total of 535 MSM
including 226 MBs and 309 general MSM were recruited to participate in a
cross-sectional survey including a face-to-face questionnaire interview and HIV
testing. Genotyping of HIV-1 pol gene was performed for HIV-positive
participants. Compared with general MSM, MBs reported more sexual partners, more
alcohol and drug use and more sex after alcohol or drug use. HIV prevalence was
10.7% overall, 14.6% for MBs and 7.8% for general MSM (p=0.011). Two independent
multiple logistic regression analyses indicated that HIV infection was positively
associated with non-Han ethnicity (Odds Ratio [OR]=4.79, 95% Confidence Interval
[CI]: 1.08-21.28) and sex after drug use in the past 6months (OR=3.59, 95% CI:
1.50-8.61) among MBs, and with sex after drug use in the past 6months (OR=3.38,
95% CI: 1.10-10.34) among general MSM as well. HIV-1 pol gene was successfully
amplified and sequenced for 52 (91.2%) of HIV-positive participants. Of them,
53.8% were genotyped as CRF01_AE, 36.5% as CRF07_BC and 9.6% as subtype B. Two
CRF01_AE subtype-infected participants (3.8%), a 50years old MB and a 24years old
general MSM, harbored viruses with a M46L mutation conferring resistance to
protease inhibitors (PI). MSM particularly MBs in Shanghai, China were at high
risk of HIV infection, underscoring an urgent need for joint intervention efforts
for drug use and sexual behaviors. HIV drug resistance surveillance is also
warranted although the relatively low prevalence of HIV drug resistance implies
the effectiveness of current antiretroviral treatment regimen.