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10.1007/s12264-013-1322-2 http://scihub22266oqcxt.onion/10.1007/s12264-013-1322-2 C4395498!4395498!23558589     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Bull 2013 ; 29 (2): 199-215 Nephropedia Template TP {{tp|p=23558589|t=2013. Signaling mechanisms regulating myelination in the central nervous system |pdf=|usr=}}{{23558589}} gab.com Text Signaling mechanisms regulating myelination in the central nervous system JO: Neurosci Bull http://www.kidney.de/pget.php?&tw=1&pmid=23558589 #FOAvip The precise and coordinated production of myelin is essential for proper development and function of the nervous system. Diseases that disrupt myelin, including multiple sclerosis, cause significant functional disability. Current treatment aims to reduce the inflammatory component of the disease, thereby preventing damage resulting from demyelination. However, therapies are not yet available to improve natural repair processes after damage has already occurred. A thorough understanding of the signaling mechanisms that regulate myelin generation will improve our ability to enhance repair. in this review, we summarize the positive and negative regulators of myelination, focusing primarily on central nervous system myelination. Axon-derived signals, extracellular signals from both diffusible factors and the extracellular matrix, and intracellular signaling pathways within myelinating oligodendrocytes are discussed. Much is known about the positive regulators that drive myelination, while less is known about the negative regulators that shift active myelination to myelin maintenance at the appropriate time. Therefore, we also provide new data on potential negative regulators of CNS myelination. Twit Text FOAVip Signaling mechanisms regulating myelination in the central nervous system ????Neurosci Bull http://www.kidney.de/pget.php?&tw=1&pmid=23558589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23558589 #FOAvip English Wikipedia <ref>{{Cite pmid|23558589}}</ref> Signaling mechanisms regulating myelination in the central nervous system #MMPMID23558589 Ahrendsen JT; Macklin W Neurosci Bull 2013[Apr]; 29 (2): 199-215 PMID23558589show ga The precise and coordinated production of myelin is essential for proper development and function of the nervous system. Diseases that disrupt myelin, including multiple sclerosis, cause significant functional disability. Current treatment aims to reduce the inflammatory component of the disease, thereby preventing damage resulting from demyelination. However, therapies are not yet available to improve natural repair processes after damage has already occurred. A thorough understanding of the signaling mechanisms that regulate myelin generation will improve our ability to enhance repair. in this review, we summarize the positive and negative regulators of myelination, focusing primarily on central nervous system myelination. Axon-derived signals, extracellular signals from both diffusible factors and the extracellular matrix, and intracellular signaling pathways within myelinating oligodendrocytes are discussed. Much is known about the positive regulators that drive myelination, while less is known about the negative regulators that shift active myelination to myelin maintenance at the appropriate time. Therefore, we also provide new data on potential negative regulators of CNS myelination. äSignaling mechanisms regulating myelination in the central nervous sys(epmc).pdf DeepDyve Pubget Overpricing