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10.1083/jcb.201407130 http://scihub22266oqcxt.onion/10.1083/jcb.201407130 C4395477!4395477 !25869671     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25869671 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 209 (1 ): 143-62 Nephropedia Template TP {{tp|p=25869671 |t=2015. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse |pdf=|usr=}}{{25869671 }} gab.com Text TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25869671 #FOAvip The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2--an actin-binding protein predominantly expressed in T cells--in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2(-/-)) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2(-/-) T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS. Twit Text FOAVip TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25869671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25869671 #FOAvip English Wikipedia <ref>{{Cite pmid|25869671 }}</ref> TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse #MMPMID25869671 Na BR ; Kim HR ; Piragyte I ; Oh HM ; Kwon MS ; Akber U ; Lee HS ; Park DS ; Song WK ; Park ZY ; Im SH ; Rho MC ; Hyun YM ; Kim M ; Jun CD J Cell Biol 2015[Apr]; 209 (1 ): 143-62 PMID25869671 show ga The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2--an actin-binding protein predominantly expressed in T cells--in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2(-/-)) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2(-/-) T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS. |Actin Cytoskeleton/*metabolism [MESH] |Actin Depolymerizing Factors/metabolism [MESH] |Animals [MESH] |Binding, Competitive [MESH] |CHO Cells [MESH] |Cricetinae [MESH] |Cricetulus [MESH] |Humans [MESH] |Immunological Synapses/*metabolism/ultrastructure [MESH] |Jurkat Cells [MESH] |Lymphocyte Activation [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Microfilament Proteins/*physiology [MESH] |Muscle Proteins/*physiology [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH]TAGLN2 regulates T cell activation by stabilizing the actin cytoskelet(epmc).pdf DeepDyve Pubget Overpricing