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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Ther 2015 ; 37 (3): 540-51 Nephropedia Template TP
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Salivary Extracellular Non-Coding RNA: Emerging Biomarkers for Molecular Diagnostics #MMPMID25795433
Wong DT
Clin Ther 2015[Mar]; 37 (3): 540-51 PMID25795433show ga
Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, nourished by body?s vasculature. While many circulatory molecules (DNA, RNA and proteins) could also be present in saliva, saliva harbors unique molecular constituents that can be discriminatory for oral and systemic disease screening and detection. Many studies have reported that salivary constituents can discriminate oral diseases (oral cancer and Sjögren?s Syndrome) and also systemic diseases (lung cancer, breast cancer, pancreatic cancer and ovarian cancer). Non-coding RNAs (ncRNAs) are emerging new regulators of diverse biological functions, playing important roles in oncogenesis and tumor progression. Indeed, the short size of these molecules makes them very stable in different body fluids such as urine, blood and saliva, being not as susceptible as mRNAs to degradation by RNases. Here, we reviewed the current status and clinical implications of the ncRNAs present in human saliva for translational applications and basic biological research. The development of non-invasive salivary test (based on ncRNAs profiles) for disease detection, could have impactful applications into the clinical context with a translational significance as emerging molecular biomarkers for non-invasively disease detection, not only by reducing the cost to the healthcare system, but also benefitting patients.