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Modeling and predicting hemorrhagic fever with renal syndrome trends based on
meteorological factors in Hu County, China
#MMPMID25875211
Xiao D
; Wu K
; Tan X
; Le J
; Li H
; Yan Y
; Xu Z
PLoS One
2015[]; 10
(4
): e0123166
PMID25875211
show ga
BACKGROUND: Hu County is a serious hemorrhagic fever with renal syndrome (HFRS)
epidemic area, with notable fluctuation of the HFRS epidemic in recent years.
This study aimed to explore the optimal model for HFRS epidemic prediction in Hu.
METHODS: Three models were constructed and compared, including a generalized
linear model (GLM), a generalized additive model (GAM), and a principal
components regression model (PCRM). The fitting and predictive adjusted R2 of
each model were calculated. Ljung-Box Q tests for fitted and predicted residuals
of each model were conducted. The study period was stratified into before
(1971-1993) and after (1994-2012) vaccine implementation epochs to avoid the
confounding factor of vaccination. RESULTS: The autocorrelation of fitted and
predicted residuals of the GAM in the two epochs were not significant (Ljung-Box
Q test, P>.05). The adjusted R2 for the predictive abilities of the GLM, GAM, and
PCRM were 0.752, 0.799, and 0.665 in the early epoch, and 0.669, 0.756, and 0.574
in the recent epoch. The adjusted R2 values of the three models were lower in the
early epoch than in the recent epoch. CONCLUSIONS: GAM is superior to GLM and
PCRM for monthly HFRS case number prediction in Hu County. A shift in model
reliability coincident with vaccination implementation demonstrates the
importance of vaccination in HFRS control and prevention.
|*Meteorological Concepts
[MESH]
|*Models, Statistical
[MESH]
|Algorithms
[MESH]
|China/epidemiology
[MESH]
|Hemorrhagic Fever with Renal Syndrome/*epidemiology
[MESH]