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10.1128/AAC.04853-14 http://scihub22266oqcxt.onion/10.1128/AAC.04853-14 C4394778!4394778!25691641     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antimicrob+Agents+Chemother 2015 ; 59 (5): 2525-30 Nephropedia Template TP {{tp|p=25691641|t=2015. Ambush of Clostridium difficile Spores by Ramoplanin: Activity in an In Vitro Model |pdf=|usr=}}{{25691641}} gab.com Text Ambush of Clostridium difficile Spores by Ramoplanin: Activity in an In Vitro Model JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25691641 #FOAvip Clostridium difficile infection (CDI) is a gastrointestinal disease caused by C. difficile, a spore-forming bacterium that in its spore form is tolerant to standard antimicrobials. Ramoplanin is a glycolipodepsipeptide antibiotic that is active against C. difficile with MICs ranging from 0.25 to 0.50 ?g/ml. The activity of ramoplanin against the spores of C. difficile has not been well characterized; such activity, however, may hold promise, since posttreatment residual intraluminal spores are likely elements of disease relapse, which can impact more than 20% of patients who are successfully treated. C. difficile spores were found to be stable in deionized water for 6 days. In vitro spore counts were consistently below the level of detection for 28 days after even brief (30-min) exposure to ramoplanin at concentrations found in feces (300 ?g/ml). In contrast, suppression of spore counts was not observed for metronidazole or vancomycin at human fecal concentrations during treatment (10 ?g/ml and 500 ?g/ml, respectively). Removal of the C. difficile exosporium resulted in an increase in spore counts after exposure to 300 ?g/ml of ramoplanin. Therefore, we propose that rather than being directly sporicidal, ramoplanin adheres to the exosporium for a prolonged period, during which time it is available to attack germinating cells. This action, in conjunction with its already established bactericidal activity against vegetative C. difficile forms, supports further evaluation of ramoplanin for the prevention of relapse after C. difficile infection in patients. Twit Text FOAVip Ambush of Clostridium difficile Spores by Ramoplanin: Activity in an In Vitro Model ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25691641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25691641 #FOAvip English Wikipedia <ref>{{Cite pmid|25691641}}</ref> Ambush of Clostridium difficile Spores by Ramoplanin: Activity in an In Vitro Model #MMPMID25691641 Kraus CN; Lyerly MW; Carman RJ Antimicrob Agents Chemother 2015[May]; 59 (5): 2525-30 PMID25691641show ga Clostridium difficile infection (CDI) is a gastrointestinal disease caused by C. difficile, a spore-forming bacterium that in its spore form is tolerant to standard antimicrobials. Ramoplanin is a glycolipodepsipeptide antibiotic that is active against C. difficile with MICs ranging from 0.25 to 0.50 ?g/ml. The activity of ramoplanin against the spores of C. difficile has not been well characterized; such activity, however, may hold promise, since posttreatment residual intraluminal spores are likely elements of disease relapse, which can impact more than 20% of patients who are successfully treated. C. difficile spores were found to be stable in deionized water for 6 days. In vitro spore counts were consistently below the level of detection for 28 days after even brief (30-min) exposure to ramoplanin at concentrations found in feces (300 ?g/ml). In contrast, suppression of spore counts was not observed for metronidazole or vancomycin at human fecal concentrations during treatment (10 ?g/ml and 500 ?g/ml, respectively). Removal of the C. difficile exosporium resulted in an increase in spore counts after exposure to 300 ?g/ml of ramoplanin. Therefore, we propose that rather than being directly sporicidal, ramoplanin adheres to the exosporium for a prolonged period, during which time it is available to attack germinating cells. This action, in conjunction with its already established bactericidal activity against vegetative C. difficile forms, supports further evaluation of ramoplanin for the prevention of relapse after C. difficile infection in patients. äAmbush of Clostridium difficile Spores by Ramoplanin: Activity in an I(epmc).pdf DeepDyve Pubget Overpricing