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10.3389/fcell.2015.00024 http://scihub22266oqcxt.onion/10.3389/fcell.2015.00024 C4394695!4394695!25918701     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Dev+Biol 2015 ; 3 (ä): ä Nephropedia Template TP {{tp|p=25918701|t=2015. Nuclear PI3K signaling in cell growth and tumorigenesis |pdf=|usr=}}{{25918701}} gab.com Text Nuclear PI3K signaling in cell growth and tumorigenesis JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25918701 #FOAvip The PI3K/Akt signaling pathway is a major driving force in a variety of cellular functions. Dysregulation of this pathway has been implicated in many human diseases including cancer. While the activity of the cytoplasmic PI3K/Akt pathway has been extensively studied, the functions of these molecules and their effector proteins within the nucleus are poorly understood. Harboring key cellular processes such as DNA replication and repair as well as nascent messenger RNA transcription, the nucleus provides a unique compartmental environment for protein?protein and protein?DNA/RNA interactions required for cell survival, growth, and proliferation. Here we summarize recent advances made toward elucidating the nuclear PI3K/Akt signaling cascade and its key components within the nucleus as they pertain to cell growth and tumorigenesis. This review covers the spatial and temporal localization of the major nuclear kinases having PI3K activities and the counteracting phosphatases as well as the role of nuclear PI3K/Akt signaling in mRNA processing and exportation, DNA replication and repair, ribosome biogenesis, cell survival, and tumorigenesis. Twit Text FOAVip Nuclear PI3K signaling in cell growth and tumorigenesis ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25918701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25918701 #FOAvip English Wikipedia <ref>{{Cite pmid|25918701}}</ref> Nuclear PI3K signaling in cell growth and tumorigenesis #MMPMID25918701 Davis WJ; Lehmann PZ; Li W Front Cell Dev Biol 2015[]; 3 (ä): ä PMID25918701show ga The PI3K/Akt signaling pathway is a major driving force in a variety of cellular functions. Dysregulation of this pathway has been implicated in many human diseases including cancer. While the activity of the cytoplasmic PI3K/Akt pathway has been extensively studied, the functions of these molecules and their effector proteins within the nucleus are poorly understood. Harboring key cellular processes such as DNA replication and repair as well as nascent messenger RNA transcription, the nucleus provides a unique compartmental environment for protein?protein and protein?DNA/RNA interactions required for cell survival, growth, and proliferation. Here we summarize recent advances made toward elucidating the nuclear PI3K/Akt signaling cascade and its key components within the nucleus as they pertain to cell growth and tumorigenesis. This review covers the spatial and temporal localization of the major nuclear kinases having PI3K activities and the counteracting phosphatases as well as the role of nuclear PI3K/Akt signaling in mRNA processing and exportation, DNA replication and repair, ribosome biogenesis, cell survival, and tumorigenesis. äNuclear PI3K signaling in cell growth and tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing