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10.1124/pr.114.009928 http://scihub22266oqcxt.onion/10.1124/pr.114.009928 C4394686!4394686 !25829385     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25829385 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pharmacol+Rev 2015 ; 67 (2 ): 462-504 Nephropedia Template TP {{tp|p=25829385 |t=2015. International Union of Basic and Clinical Pharmacology XCVI Pattern recognition receptors in health and disease |pdf=|usr=}}{{25829385 }} gab.com Text International Union of Basic and Clinical Pharmacology XCVI Pattern recognition receptors in health and disease JO: Pharmacol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25829385 #FOAvip Since the discovery of Toll, in the fruit fly Drosophila melanogaster, as the first described pattern recognition receptor (PRR) in 1996, many families of these receptors have been discovered and characterized. PRRs play critically important roles in pathogen recognition to initiate innate immune responses that ultimately link to the generation of adaptive immunity. Activation of PRRs leads to the induction of immune and inflammatory genes, including proinflammatory cytokines and chemokines. It is increasingly clear that many PRRs are linked to a range of inflammatory, infectious, immune, and chronic degenerative diseases. Several drugs to modulate PRR activity are already in clinical trials and many more are likely to appear in the near future. Here, we review the different families of mammalian PRRs, the ligands they recognize, the mechanisms of activation, their role in disease, and the potential of targeting these proteins to develop the anti-inflammatory therapeutics of the future. Twit Text FOAVip International Union of Basic and Clinical Pharmacology XCVI Pattern recognition receptors in health and disease ????Pharmacol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25829385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25829385 #FOAvip English Wikipedia <ref>{{Cite pmid|25829385 }}</ref> International Union of Basic and Clinical Pharmacology XCVI Pattern recognition receptors in health and disease #MMPMID25829385 Bryant CE ; Orr S ; Ferguson B ; Symmons MF ; Boyle JP ; Monie TP Pharmacol Rev 2015[]; 67 (2 ): 462-504 PMID25829385 show ga Since the discovery of Toll, in the fruit fly Drosophila melanogaster, as the first described pattern recognition receptor (PRR) in 1996, many families of these receptors have been discovered and characterized. PRRs play critically important roles in pathogen recognition to initiate innate immune responses that ultimately link to the generation of adaptive immunity. Activation of PRRs leads to the induction of immune and inflammatory genes, including proinflammatory cytokines and chemokines. It is increasingly clear that many PRRs are linked to a range of inflammatory, infectious, immune, and chronic degenerative diseases. Several drugs to modulate PRR activity are already in clinical trials and many more are likely to appear in the near future. Here, we review the different families of mammalian PRRs, the ligands they recognize, the mechanisms of activation, their role in disease, and the potential of targeting these proteins to develop the anti-inflammatory therapeutics of the future. |*Chronic Disease [MESH] |*Models, Molecular [MESH] |*Mutation [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Membrane/enzymology/metabolism [MESH] |Endosomes/enzymology/metabolism [MESH] |Humans [MESH] |Inflammasomes/metabolism [MESH] |International Agencies [MESH] |Ligands [MESH] |Mitochondrial Membranes/enzymology/metabolism [MESH] |Pharmacology, Clinical/trends [MESH] |Pharmacology/trends [MESH] |Protein Isoforms/chemistry/classification/metabolism [MESH] |Protein Processing, Post-Translational [MESH] |Receptors, Pattern Recognition/chemistry/classification/*genetics/*metabolism [MESH] |Societies, Scientific [MESH]International Union of Basic and Clinical Pharmacology XCVI Pattern (epmc).pdf DeepDyve Pubget Overpricing