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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Endocrinol+Metab
2015 ; 13
(2
): e23542
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English Wikipedia
Resveratrol-Dependent Down-regulation of Receptor for Advanced Glycation
End-products and Oxidative Stress in Kidney of Rats With Diabetes
#MMPMID25892997
Moridi H
; Karimi J
; Sheikh N
; Goodarzi MT
; Saidijam M
; Yadegarazari R
; Khazaei M
; Khodadadi I
; Tavilani H
; Piri H
; Asadi S
; Zarei S
; Rezaei A
Int J Endocrinol Metab
2015[Apr]; 13
(2
): e23542
PMID25892997
show ga
BACKGROUND: Millions of people in the world have diabetes mellitus and its
prevalence is growing. Oxidative stress, advanced glycation end-products (AGEs)
and receptor for advanced glycation end-products (RAGE) play key role in the
pathogenesis of diabetes. New and safe strategies of remedy are needed for this
disease. OBJECTIVES: We hypothesized that resveratrol may exert a renal
protective effect on diabetic rats. MATERIALS AND METHODS: Male rats with
diabetes were treated with or without resveratrol as 1, 5, 10 mg/kg of body
weight for 30 days. The total AGEs and malondialdehyde levels in kidney tissues
were determined by spectro?uorimetric method and the insulin level was assayed
using ELISA. The total antioxidant capacity contents in kidney and the glucose in
plasma were measured by a colorimetric assay. The expression of RAGE was assayed
in kidneys of all animals using quantitative PCR. RESULTS: In resveratrol-treated
rats with diabetes, malondialdehyde levels, plasma glucose and expression of RAGE
were significantly reduced compared with the untreated group. Moreover, the total
antioxidant and insulin levels significantly increased in treated rats. There was
no significant difference in the AGEs contents among all the groups. CONCLUSIONS:
These results revealed that resveratrol has beneficial effects on kidney by
extenuating the oxidative stress and down-regulation of RAGE expression.