Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.acap.2009.02.002 http://scihub22266oqcxt.onion/10.1016/j.acap.2009.02.002 C4394390!4394390!19450778     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acad+Pediatr 2009 ; 9 (3): 179-84 Nephropedia Template TP {{tp|p=19450778|t=2009. Antibiotic Selection for Purulent Skin and Soft-Tissue Infections in Ambulatory Care: A Decision-Analytic Approach |pdf=|usr=}}{{19450778}} gab.com Text Antibiotic Selection for Purulent Skin and Soft-Tissue Infections in Ambulatory Care: A Decision-Analytic Approach JO: Acad Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=19450778 #FOAvip Background: Community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) has caused an nationwide epidemic of skin and soft-tissue infections (SSTIs) in ambulatory pediatrics. Antibiotic treatment recommendations suggest incorporating local epidemiology for the prevalence of CA-MRSA. We sought to identify the antibiotic strategy with the highest probability of activity and to identify threshold values for epidemiologic variables including bacterial prevalence and antibiotic resistance. Methods: We used decision analysis to evaluate three empiric antibiotic strategies: (1) clindamycin, (2) trimethoprim/sulfamethoxazole (T/S) and (3) cephalexin. We calculated the probability of activity against the bacteria causing the infection (CA-MRSA, methicillin-sensitive S. aureus and group A Streptococcus) by incorporating estimates of prevalence and antibiotic resistance to determine the optimal strategy. Sensitivity analysis was used to identify thresholds for prevalence and antibiotic resistance where two strategies were equal. Results: Clindamycin (0.95) and T/S (0.89) had substantially higher probability of activity than cephalexin (0.28) using baseline estimates for bacterial prevalence and antibiotic resistance. Cephalexin was the optimal antibiotic only when CA-MRSA prevalence was <10%. The probability of activity for clindamycin and T/S was highly sensitive to changes in the values for bacterial prevalence (both CA-MRSA and group A Streptococcus) and CA-MRSA resistance to clindamycin. Conclusions: Empiric treatment of SSTIs with either clindamycin or T/S maximizes the probability that the antibiotic will be active when CA-MRSA prevalence is >10%. Deciding between T/S and clindamycin requires consideration of antibiotic resistance and prevalence of group A Streptococcus. This model can be customized to local communities and illustrates the importance of ongoing epidemiologic surveillance in primary care settings. Twit Text FOAVip Antibiotic Selection for Purulent Skin and Soft-Tissue Infections in Ambulatory Care: A Decision-Analytic Approach ????Acad Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=19450778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19450778 #FOAvip English Wikipedia <ref>{{Cite pmid|19450778}}</ref> Antibiotic Selection for Purulent Skin and Soft-Tissue Infections in Ambulatory Care: A Decision-Analytic Approach #MMPMID19450778 Hersh AL; Weintrub PS; Cabana MD Acad Pediatr 2009[May]; 9 (3): 179-84 PMID19450778show ga Background: Community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) has caused an nationwide epidemic of skin and soft-tissue infections (SSTIs) in ambulatory pediatrics. Antibiotic treatment recommendations suggest incorporating local epidemiology for the prevalence of CA-MRSA. We sought to identify the antibiotic strategy with the highest probability of activity and to identify threshold values for epidemiologic variables including bacterial prevalence and antibiotic resistance. Methods: We used decision analysis to evaluate three empiric antibiotic strategies: (1) clindamycin, (2) trimethoprim/sulfamethoxazole (T/S) and (3) cephalexin. We calculated the probability of activity against the bacteria causing the infection (CA-MRSA, methicillin-sensitive S. aureus and group A Streptococcus) by incorporating estimates of prevalence and antibiotic resistance to determine the optimal strategy. Sensitivity analysis was used to identify thresholds for prevalence and antibiotic resistance where two strategies were equal. Results: Clindamycin (0.95) and T/S (0.89) had substantially higher probability of activity than cephalexin (0.28) using baseline estimates for bacterial prevalence and antibiotic resistance. Cephalexin was the optimal antibiotic only when CA-MRSA prevalence was <10%. The probability of activity for clindamycin and T/S was highly sensitive to changes in the values for bacterial prevalence (both CA-MRSA and group A Streptococcus) and CA-MRSA resistance to clindamycin. Conclusions: Empiric treatment of SSTIs with either clindamycin or T/S maximizes the probability that the antibiotic will be active when CA-MRSA prevalence is >10%. Deciding between T/S and clindamycin requires consideration of antibiotic resistance and prevalence of group A Streptococcus. This model can be customized to local communities and illustrates the importance of ongoing epidemiologic surveillance in primary care settings. äAntibiotic Selection for Purulent Skin and Soft-Tissue Infections in A(epmc).pdf DeepDyve Pubget Overpricing