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10.1073/pnas.1421441112 http://scihub22266oqcxt.onion/10.1073/pnas.1421441112 C4394310!4394310!25831548     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (14): 4340-5 Nephropedia Template TP {{tp|p=25831548|t=2015. KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 |pdf=|usr=}}{{25831548}} gab.com Text KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25831548 #FOAvip The role of tight junction permeability in causing human diseases is an important but understudied area. Here, we discovered a previously unidentified mechanism in the kidney that uses the Kelch-like 3-dependent ubiquitination pathway to regulate claudin-8 and the paracellular permeability to chloride. The importance of posttranslational regulation of tight junction structure and function is shown here, with emphasis on its potential role in causing human hypertension if a proper ubiquitination pathway is disrupted by genetic mutations. Such a mechanism may also be explored as a pharmacologic tool to correct tight junction permeability defects and related diseases. Twit Text FOAVip KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25831548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25831548 #FOAvip English Wikipedia <ref>{{Cite pmid|25831548}}</ref> KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 #MMPMID25831548 Gong Y; Wang J; Yang J; Gonzales E; Perez R; Hou J Proc Natl Acad Sci U S A 2015[Apr]; 112 (14): 4340-5 PMID25831548show ga The role of tight junction permeability in causing human diseases is an important but understudied area. Here, we discovered a previously unidentified mechanism in the kidney that uses the Kelch-like 3-dependent ubiquitination pathway to regulate claudin-8 and the paracellular permeability to chloride. The importance of posttranslational regulation of tight junction structure and function is shown here, with emphasis on its potential role in causing human hypertension if a proper ubiquitination pathway is disrupted by genetic mutations. Such a mechanism may also be explored as a pharmacologic tool to correct tight junction permeability defects and related diseases. äKLHL3 regulates paracellular chloride transport in the kidney by ubiqu(epmc).pdf DeepDyve Pubget Overpricing