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10.1073/pnas.1417594112 http://scihub22266oqcxt.onion/10.1073/pnas.1417594112 C4394259!4394259!25831490     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (14): 4286-91 Nephropedia Template TP {{tp|p=25831490|t=2015. Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures |pdf=|usr=}}{{25831490}} gab.com Text Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25831490 #FOAvip RecQ DNA helicases are critical enzymes for the maintenance of genome integrity. Here, we determined the first DNA complex structures, to our knowledge, of the human RECQ1 helicase. These structures provide new insight into the RecQ helicase mechanism of DNA tracking, strand separation, strand annealing, and Holliday junction (HJ) branch migration. We identified a surface region in the winged-helix domain of RECQ1 that is important for both dsDNA recognition and HJ resolution, and we used a combination of biochemical, analytical ultracentrifugation, and EM experiments to begin elucidating the molecular basis of the distinct HJ resolution activities of human RecQ helicases. Twit Text FOAVip Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25831490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25831490 #FOAvip English Wikipedia <ref>{{Cite pmid|25831490}}</ref> Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures #MMPMID25831490 Pike ACW; Gomathinayagam S; Swuec P; Berti M; Zhang Y; Schnecke C; Marino F; von Delft F; Renault L; Costa A; Gileadi O; Vindigni A Proc Natl Acad Sci U S A 2015[Apr]; 112 (14): 4286-91 PMID25831490show ga RecQ DNA helicases are critical enzymes for the maintenance of genome integrity. Here, we determined the first DNA complex structures, to our knowledge, of the human RECQ1 helicase. These structures provide new insight into the RecQ helicase mechanism of DNA tracking, strand separation, strand annealing, and Holliday junction (HJ) branch migration. We identified a surface region in the winged-helix domain of RECQ1 that is important for both dsDNA recognition and HJ resolution, and we used a combination of biochemical, analytical ultracentrifugation, and EM experiments to begin elucidating the molecular basis of the distinct HJ resolution activities of human RecQ helicases. äHuman RECQ1 helicase-driven DNA unwinding, annealing, and branch migra(epmc).pdf DeepDyve Pubget Overpricing