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10.1073/pnas.1420363112 http://scihub22266oqcxt.onion/10.1073/pnas.1420363112 C4394251!4394251!25805819     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (14): 4447-52 Nephropedia Template TP {{tp|p=25805819|t=2015. Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development |pdf=|usr=}}{{25805819}} gab.com Text Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip Smooth muscle cells (SMCs) play critical roles in maintaining organismal homeostasis. Myocardin is a muscle-restricted transcriptional coactivator previously implicated in development of the heart and vasculature. To define myocardin-mediated functions during postnatal development, we generated mice harboring an inducible, SMC-restricted mutation in the Myocd gene. Myocardin mutant mice exhibit profound derangements in arterial structure and in the gastrointestinal and genitourinary tracts. Myocd deletion leads to the loss of the contractile SMC phenotype, triggering cell-autonomous ER stress, autophagy, and apoptosis. These data reveal that myocardin is required for maintenance, homeostasis, and ultimately survival of vascular and visceral SMCs during postnatal development. These findings provide unanticipated insights into the pathogenesis of thoracic aortic aneurysm and dissection and gastrointestinal and genitourinary syndromes. Twit Text FOAVip Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip English Wikipedia <ref>{{Cite pmid|25805819}}</ref> Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development #MMPMID25805819 Huang J; Wang T; Wright AC; Yang J; Zhou S; Li L; Yang J; Small A; Parmacek MS Proc Natl Acad Sci U S A 2015[Apr]; 112 (14): 4447-52 PMID25805819show ga Smooth muscle cells (SMCs) play critical roles in maintaining organismal homeostasis. Myocardin is a muscle-restricted transcriptional coactivator previously implicated in development of the heart and vasculature. To define myocardin-mediated functions during postnatal development, we generated mice harboring an inducible, SMC-restricted mutation in the Myocd gene. Myocardin mutant mice exhibit profound derangements in arterial structure and in the gastrointestinal and genitourinary tracts. Myocd deletion leads to the loss of the contractile SMC phenotype, triggering cell-autonomous ER stress, autophagy, and apoptosis. These data reveal that myocardin is required for maintenance, homeostasis, and ultimately survival of vascular and visceral SMCs during postnatal development. These findings provide unanticipated insights into the pathogenesis of thoracic aortic aneurysm and dissection and gastrointestinal and genitourinary syndromes. äMyocardin is required for maintenance of vascular and visceral smooth (epmc).pdf DeepDyve Pubget Overpricing