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10.1073/pnas.1420363112 http://scihub22266oqcxt.onion/10.1073/pnas.1420363112 C4394251!4394251 !25805819     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25805819 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (14 ): 4447-52 Nephropedia Template TP {{tp|p=25805819 |t=2015. Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development |pdf=|usr=}}{{25805819 }} gab.com Text Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival. To identify myocardin-dependent functions in smooth muscle cells (SMCs) during postnatal development, mice harboring a SMC-restricted conditional, inducible Myocd null mutation were generated and characterized. Tamoxifen-treated SMMHC-Cre(ERT2)/Myocd(F/F) conditional mutant mice die within 6 mo of Myocd gene deletion, exhibiting profound derangements in the structure of great arteries as well as the gastrointestinal and genitourinary tracts. Conditional mutant mice develop arterial aneurysms, dissection, and rupture, recapitulating pathology observed in heritable forms of thoracic aortic aneurysm and dissection (TAAD). SMCs populating arteries of Myocd conditional mutant mice modulate their phenotype by down-regulation of SMC contractile genes and up-regulation of extracellular matrix proteins. Surprisingly, this is accompanied by SMC autonomous activation of endoplasmic reticulum (ER) stress and autophagy, which over time progress to programmed cell death. Consistent with these observations, Myocd conditional mutant mice develop remarkable dilation of the stomach, small intestine, bladder, and ureters attributable to the loss of visceral SMCs disrupting the muscularis mucosa. Taken together, these data demonstrate that during postnatal development, myocardin plays a unique, and important, role required for maintenance and homeostasis of the vasculature, gastrointestinal, and genitourinary tracts. The loss of myocardin in SMCs triggers ER stress and autophagy, which transitions to apoptosis, revealing evolutionary conservation of myocardin function in SMCs and cardiomyocytes. Twit Text FOAVip Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25805819 #FOAvip English Wikipedia <ref>{{Cite pmid|25805819 }}</ref> Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development #MMPMID25805819 Huang J ; Wang T ; Wright AC ; Yang J ; Zhou S ; Li L ; Yang J ; Small A ; Parmacek MS Proc Natl Acad Sci U S A 2015[Apr]; 112 (14 ): 4447-52 PMID25805819 show ga Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival. To identify myocardin-dependent functions in smooth muscle cells (SMCs) during postnatal development, mice harboring a SMC-restricted conditional, inducible Myocd null mutation were generated and characterized. Tamoxifen-treated SMMHC-Cre(ERT2)/Myocd(F/F) conditional mutant mice die within 6 mo of Myocd gene deletion, exhibiting profound derangements in the structure of great arteries as well as the gastrointestinal and genitourinary tracts. Conditional mutant mice develop arterial aneurysms, dissection, and rupture, recapitulating pathology observed in heritable forms of thoracic aortic aneurysm and dissection (TAAD). SMCs populating arteries of Myocd conditional mutant mice modulate their phenotype by down-regulation of SMC contractile genes and up-regulation of extracellular matrix proteins. Surprisingly, this is accompanied by SMC autonomous activation of endoplasmic reticulum (ER) stress and autophagy, which over time progress to programmed cell death. Consistent with these observations, Myocd conditional mutant mice develop remarkable dilation of the stomach, small intestine, bladder, and ureters attributable to the loss of visceral SMCs disrupting the muscularis mucosa. Taken together, these data demonstrate that during postnatal development, myocardin plays a unique, and important, role required for maintenance and homeostasis of the vasculature, gastrointestinal, and genitourinary tracts. The loss of myocardin in SMCs triggers ER stress and autophagy, which transitions to apoptosis, revealing evolutionary conservation of myocardin function in SMCs and cardiomyocytes. |*Gene Expression Regulation, Developmental [MESH] |Animals [MESH] |Aorta/metabolism [MESH] |Aortic Aneurysm/*metabolism [MESH] |Apoptosis [MESH] |Autophagy [MESH] |Gastrointestinal Tract/metabolism [MESH] |Homeostasis [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Muscle Contraction [MESH] |Muscle, Smooth, Vascular/*metabolism [MESH] |Mutation [MESH] |Myocardium/metabolism [MESH] |Myocytes, Smooth Muscle/cytology [MESH] |Nuclear Proteins/*genetics/*physiology [MESH] |Phenotype [MESH] |Tamoxifen/chemistry [MESH] |Trans-Activators/*genetics/*physiology [MESH]Myocardin is required for maintenance of vascular and visceral smooth (epmc).pdf DeepDyve Pubget Overpricing