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10.1016/j.celrep.2015.03.007 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.03.007 C4394041!4394041!25818302     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 11 (1): 33-42 Nephropedia Template TP {{tp|p=25818302|t=2015. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis |pdf=|usr=}}{{25818302}} gab.com Text Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25818302 #FOAvip Proper organ homeostasis requires tight control of adult stem cells and differentiation through integration of multiple inputs. In the mouse small intestine, Notch and Wnt signaling are required both for stem cell maintenance and for a proper balance of differentiation between secretory and absorptive cell lineages. In the absence of Notch signaling, stem cells preferentially generate secretory cells at the expense of absorptive cells. Here, we use function-blocking antibodies against Notch receptors to demonstrate that Notch blockade perturbs intestinal stem cell function by causing a de-repression of the Wnt signaling pathway, leading to mis-expression of prosecretory genes. Importantly, attenuation of the Wnt pathway rescued the phenotype associated with Notch blockade. These studies bring to light a negative regulatory mechanism that maintains stem cell activity and balanced differentiation, and we propose that the interaction between Wnt and Notch signaling described here represents a common theme in adult stem cell biology. Twit Text FOAVip Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25818302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25818302 #FOAvip English Wikipedia <ref>{{Cite pmid|25818302}}</ref> Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis #MMPMID25818302 Tian H; Biehs B; Chiu C; Siebel C; Wu Y; Costa M; de Sauvage FJ; Klein OD Cell Rep 2015[Apr]; 11 (1): 33-42 PMID25818302show ga Proper organ homeostasis requires tight control of adult stem cells and differentiation through integration of multiple inputs. In the mouse small intestine, Notch and Wnt signaling are required both for stem cell maintenance and for a proper balance of differentiation between secretory and absorptive cell lineages. In the absence of Notch signaling, stem cells preferentially generate secretory cells at the expense of absorptive cells. Here, we use function-blocking antibodies against Notch receptors to demonstrate that Notch blockade perturbs intestinal stem cell function by causing a de-repression of the Wnt signaling pathway, leading to mis-expression of prosecretory genes. Importantly, attenuation of the Wnt pathway rescued the phenotype associated with Notch blockade. These studies bring to light a negative regulatory mechanism that maintains stem cell activity and balanced differentiation, and we propose that the interaction between Wnt and Notch signaling described here represents a common theme in adult stem cell biology. äOpposing activities of Notch and Wnt signaling regulate intestinal ste(epmc).pdf DeepDyve Pubget Overpricing