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10.3109/08958378.2013.806614 http://scihub22266oqcxt.onion/10.3109/08958378.2013.806614 C4393332!4393332 !23895351     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23895351 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Inhal+Toxicol 2013 ; 25 (9 ): 498-508 Nephropedia Template TP {{tp|p=23895351 |t=2013. Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model |pdf=|usr=}}{{23895351 }} gab.com Text Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model JO: Inhal Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=23895351 #FOAvip CONTEXT: Printers and photocopiers release respirable particles into the air. Engineered nanomaterials (ENMs) have been recently incorporated into toner formulations but their potential toxicological effects have not been well studied. OBJECTIVE: To evaluate the biological responses to copier-emitted particles in the lungs using a mouse model. METHODS: Particulate matter (PM) from a university copy center was sampled and fractionated into three distinct sizes, two of which (PM0.1 and PM0.1-2.5) were evaluated in this study. The particles were extracted and dispersed in deionized water and RPMI/10% FBS. Hydrodynamic diameter and zeta potential were evaluated by dynamic light scattering. The toxicological potential of these particles was studied using 8-week-old male Balb/c mice. Mice were intratracheally instilled with 0.2,?0.6,?2.0?mg/kg bw of either the PM0.1 and PM0.1-2.5 size fractions. Fe2O3 and welding fumes were used as comparative materials, while RPMI/10% FBS was used as the vehicle control. Bronchoalveolar lavage (BAL) was performed 24 hours post-instillation. The BAL fluid was analyzed for total and differential cell counts, and biochemical markers of injury and inflammation. RESULTS: Particle size- and dose-dependent pulmonary effects were found. Specifically, mice instilled with PM0.1 (2.0?mg/kg bw) had significant increases in neutrophil number, lactate dehydrogenase and albumin compared to vehicle control. Likewise, pro-inflammatory cytokines were elevated in mice exposed to PM0.1 (2.0?mg/kg bw) compared to other groups. CONCLUSION: Our results indicate that exposure to copier-emitted nanoparticles may induce lung injury and inflammation. Further exposure assessment and toxicological investigations are necessary to address this emerging environmental health pollutant. Twit Text FOAVip Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model ????Inhal Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=23895351 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23895351 #FOAvip English Wikipedia <ref>{{Cite pmid|23895351 }}</ref> Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model #MMPMID23895351 Pirela S ; Molina R ; Watson C ; Cohen JM ; Bello D ; Demokritou P ; Brain J Inhal Toxicol 2013[Aug]; 25 (9 ): 498-508 PMID23895351 show ga CONTEXT: Printers and photocopiers release respirable particles into the air. Engineered nanomaterials (ENMs) have been recently incorporated into toner formulations but their potential toxicological effects have not been well studied. OBJECTIVE: To evaluate the biological responses to copier-emitted particles in the lungs using a mouse model. METHODS: Particulate matter (PM) from a university copy center was sampled and fractionated into three distinct sizes, two of which (PM0.1 and PM0.1-2.5) were evaluated in this study. The particles were extracted and dispersed in deionized water and RPMI/10% FBS. Hydrodynamic diameter and zeta potential were evaluated by dynamic light scattering. The toxicological potential of these particles was studied using 8-week-old male Balb/c mice. Mice were intratracheally instilled with 0.2,?0.6,?2.0?mg/kg bw of either the PM0.1 and PM0.1-2.5 size fractions. Fe2O3 and welding fumes were used as comparative materials, while RPMI/10% FBS was used as the vehicle control. Bronchoalveolar lavage (BAL) was performed 24 hours post-instillation. The BAL fluid was analyzed for total and differential cell counts, and biochemical markers of injury and inflammation. RESULTS: Particle size- and dose-dependent pulmonary effects were found. Specifically, mice instilled with PM0.1 (2.0?mg/kg bw) had significant increases in neutrophil number, lactate dehydrogenase and albumin compared to vehicle control. Likewise, pro-inflammatory cytokines were elevated in mice exposed to PM0.1 (2.0?mg/kg bw) compared to other groups. CONCLUSION: Our results indicate that exposure to copier-emitted nanoparticles may induce lung injury and inflammation. Further exposure assessment and toxicological investigations are necessary to address this emerging environmental health pollutant. |*Ink [MESH] |*Printing [MESH] |Air Pollutants/analysis/*toxicity [MESH] |Albumins/metabolism [MESH] |Animals [MESH] |Bronchoalveolar Lavage Fluid/chemistry/cytology [MESH] |Cytokines/metabolism [MESH] |L-Lactate Dehydrogenase/metabolism [MESH] |Leukocyte Count [MESH] |Lung/*drug effects/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH]Effects of copy center particles on the lungs: a toxicological charact(epmc).pdf DeepDyve Pubget Overpricing