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10.1016/bs.ircmb.2014.12.002 http://scihub22266oqcxt.onion/10.1016/bs.ircmb.2014.12.002 C4392918!4392918!25708460     free     free     free       Int+Rev+Cell+Mol+Biol 2015 ; 315 (ä): 1-22 Nephropedia Template TP {{tp|p=25708460|t=2015. How Do Rab Proteins Determine Golgi Structure?|pdf=|usr=}}{{25708460}} gab.com Text How Do Rab Proteins Determine Golgi Structure JO: Int Rev Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25708460 #FOAvip Rab proteins, small GTPases, are key regulators of mammalian Golgi apparatus organization. Based on the effect of Rab activation state, Rab proteins fall into two functional classes. In Class1, inactivation induces Golgi ribbon fragmentation and/or redistribution of Golgi enzymes to the ER, while overexpression of wild type or activation has little, if any, effect on Golgi ribbon organization. In Class 2, the reverse is true. We give emphasis to Rab6, the most abundant Golgi-associated Rab protein. Rab6 depletion in HeLa cells causes an increase in Golgi cisternal number, longer, more continuous cisternae, and a pronounced accumulation of vesicles; the effect of Rab6 on Golgi ribbon organization is probably through regulation of vesicle transport. In effector studies, motor proteins and their regulators are found to be key Rab6 effectors. A related Rab, Rab41, affects Golgi ribbon organization in a contrasting manner. The balance between minus- and plus-end directed motor recruitment may well be the major Rab-dependent factor in Golgi ribbon organization. Twit Text FOAVip How Do Rab Proteins Determine Golgi Structure ????Int Rev Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25708460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25708460 #FOAvip English Wikipedia <ref>{{Cite pmid|25708460}}</ref> How Do Rab Proteins Determine Golgi Structure? #MMPMID25708460 Liu S; Storrie B Int Rev Cell Mol Biol 2015[]; 315 (ä): 1-22 PMID25708460show ga Rab proteins, small GTPases, are key regulators of mammalian Golgi apparatus organization. Based on the effect of Rab activation state, Rab proteins fall into two functional classes. In Class1, inactivation induces Golgi ribbon fragmentation and/or redistribution of Golgi enzymes to the ER, while overexpression of wild type or activation has little, if any, effect on Golgi ribbon organization. In Class 2, the reverse is true. We give emphasis to Rab6, the most abundant Golgi-associated Rab protein. Rab6 depletion in HeLa cells causes an increase in Golgi cisternal number, longer, more continuous cisternae, and a pronounced accumulation of vesicles; the effect of Rab6 on Golgi ribbon organization is probably through regulation of vesicle transport. In effector studies, motor proteins and their regulators are found to be key Rab6 effectors. A related Rab, Rab41, affects Golgi ribbon organization in a contrasting manner. The balance between minus- and plus-end directed motor recruitment may well be the major Rab-dependent factor in Golgi ribbon organization. äHow Do Rab Proteins Determine Golgi Structure?(epmc).pdf DeepDyve Pubget Overpricing