Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1161/JAHA.114.001594 http://scihub22266oqcxt.onion/10.1161/JAHA.114.001594 C4392439!4392439!25792129     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2015 ; 4 (3): ä Nephropedia Template TP {{tp|p=25792129|t=2015. Renal Tubule Angiotensin II Type 1 Receptor?Associated Protein Promotes Natriuresis and Inhibits Salt?Sensitive Blood Pressure Elevation |pdf=|usr=}}{{25792129}} gab.com Text Renal Tubule Angiotensin II Type 1 Receptor Associated Protein Promotes Natriuresis and Inhibits Salt Sensitive Blood Pressure Elevation JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=25792129 #FOAvip Background: Angiotensin II type 1 receptor (AT1R)?associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressure regulation in response to high salt (HS) loading, using ATRAP transgenic mice on a salt?sensitive C57BL/6J background. Methods and Results: Renal ATRAP transgenic (rATRAP?Tg) mice, which exhibit renal tubule?dominant ATRAP enhancement, and their wild?type littermate C57BL/6J mice on a normal salt diet (0.3% NaCl) at baseline were subjected to dietary HS loading (4% NaCl) for 7 days. In rATRAP?Tg mice, the dietary HS loading?mediated blood pressure elevation was suppressed compared with wild?type mice, despite similar baseline blood pressure. Although renal angiotensin II level was comparable in rATRAP?Tg and wild?type mice with and without HS loading, urinary sodium excretion in response to HS loading was significantly enhanced in the rATRAP?Tg mice. In addition, functional transport activity of the amiloride?sensitive epithelial Na+ channel was significantly decreased under saline volume?expanded conditions in rATRAP?Tg mice compared with wild?type mice, without any evident change in epithelial Na+ channel protein expression. Plasma membrane AT1R expression in the kidney of rATRAP?Tg mice was decreased compared with wild?type mice. Conclusions: These results demonstrated that distal tubule?dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to HS loading. The findings suggest that ATRAP?mediated modulation of sodium handling in renal distal tubules could be a target of interest in salt?sensitive blood pressure regulation. Twit Text FOAVip Renal Tubule Angiotensin II Type 1 Receptor Associated Protein Promotes Natriuresis and Inhibits Salt Sensitive Blood Pressure Elevation ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=25792129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25792129 #FOAvip English Wikipedia <ref>{{Cite pmid|25792129}}</ref> Renal Tubule Angiotensin II Type 1 Receptor?Associated Protein Promotes Natriuresis and Inhibits Salt?Sensitive Blood Pressure Elevation #MMPMID25792129 Wakui H; Uneda K; Tamura K; Ohsawa M; Azushima K; Kobayashi R; Ohki K; Dejima T; Kanaoka T; Tsurumi?Ikeya Y; Matsuda M; Haruhara K; Nishiyama A; Yabana M; Fujikawa T; Yamashita A; Umemura S J Am Heart Assoc 2015[Mar]; 4 (3): ä PMID25792129show ga Background: Angiotensin II type 1 receptor (AT1R)?associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressure regulation in response to high salt (HS) loading, using ATRAP transgenic mice on a salt?sensitive C57BL/6J background. Methods and Results: Renal ATRAP transgenic (rATRAP?Tg) mice, which exhibit renal tubule?dominant ATRAP enhancement, and their wild?type littermate C57BL/6J mice on a normal salt diet (0.3% NaCl) at baseline were subjected to dietary HS loading (4% NaCl) for 7 days. In rATRAP?Tg mice, the dietary HS loading?mediated blood pressure elevation was suppressed compared with wild?type mice, despite similar baseline blood pressure. Although renal angiotensin II level was comparable in rATRAP?Tg and wild?type mice with and without HS loading, urinary sodium excretion in response to HS loading was significantly enhanced in the rATRAP?Tg mice. In addition, functional transport activity of the amiloride?sensitive epithelial Na+ channel was significantly decreased under saline volume?expanded conditions in rATRAP?Tg mice compared with wild?type mice, without any evident change in epithelial Na+ channel protein expression. Plasma membrane AT1R expression in the kidney of rATRAP?Tg mice was decreased compared with wild?type mice. Conclusions: These results demonstrated that distal tubule?dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to HS loading. The findings suggest that ATRAP?mediated modulation of sodium handling in renal distal tubules could be a target of interest in salt?sensitive blood pressure regulation. äRenal Tubule Angiotensin II Type 1 Receptor?Associated Protein Promote(epmc).pdf DeepDyve Pubget Overpricing