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10.1016/j.stem.2015.02.014 http://scihub22266oqcxt.onion/10.1016/j.stem.2015.02.014 C4391962!4391962!25748932     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2015 ; 16 (3): 254-67 Nephropedia Template TP {{tp|p=25748932|t=2015. Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities |pdf=|usr=}}{{25748932}} gab.com Text Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25748932 #FOAvip Hematopoietic stem cells (HSC) rely on instructive cues from the bone marrow (BM) niche to maintain their quiescence and adapt blood production to the organism?s needs. Alterations in the BM niche are commonly observed in blood malignancies and directly contribute to the aberrant function of disease-initiating leukemic stem cells (LSC). Here, we review recent insights into the cellular and molecular determinants of the normal HSC niche and describe how genetic changes in stromal cells and leukemia-induced BM niche remodeling contribute to blood malignancies. Moreover, we discuss how these findings can be applied to non cell-autonomous therapies targeting the LSC niche. Twit Text FOAVip Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25748932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25748932 #FOAvip English Wikipedia <ref>{{Cite pmid|25748932}}</ref> Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities #MMPMID25748932 Schepers K; Campbell TB; Passegué E Cell Stem Cell 2015[Mar]; 16 (3): 254-67 PMID25748932show ga Hematopoietic stem cells (HSC) rely on instructive cues from the bone marrow (BM) niche to maintain their quiescence and adapt blood production to the organism?s needs. Alterations in the BM niche are commonly observed in blood malignancies and directly contribute to the aberrant function of disease-initiating leukemic stem cells (LSC). Here, we review recent insights into the cellular and molecular determinants of the normal HSC niche and describe how genetic changes in stromal cells and leukemia-induced BM niche remodeling contribute to blood malignancies. Moreover, we discuss how these findings can be applied to non cell-autonomous therapies targeting the LSC niche. äNormal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportu(epmc).pdf DeepDyve Pubget Overpricing