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10.1016/j.jaip.2014.09.022 http://scihub22266oqcxt.onion/10.1016/j.jaip.2014.09.022 C4391952!4391952!25609325     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25609325&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol+Pract 2015 ; 3 (2): 236-42 Nephropedia Template TP {{tp|p=25609325|t=2015. Clinical Characteristics of Adults with Chronic Rhinosinusitis and Specific Antibody Deficiency |pdf=|usr=}}{{25609325}} gab.com Text Clinical Characteristics of Adults with Chronic Rhinosinusitis and Specific Antibody Deficiency JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=25609325 #FOAvip Background: Specific antibody deficiency (SAD) involves a deficient response to a polysaccharide vaccine in the setting of normal IgG levels and chronic infections. Patients with chronic rhinosinusitis (CRS) are often evaluated for SAD. There is limited data describing patients with CRS and SAD. Objective: To better characterize the role of SAD in CRS. Methods: We reviewed electronic records of adults with CRS who were evaluated for immunodeficiency with quantitative immunoglobulin levels and pre- and post-antibody titers to a pneumococcal polysaccharide vaccine (PPV). Results: 14 pneumococcal serotypes were determined in 239 subjects from 2002?2009. 64 subjects had adequate protective titers of 1.3 ?g/mL or higher in 7 or more serotypes out of the 14 serotypes checked. 56 (23%) had less than 7 protective titers post-PPV and were diagnosed with SAD. 119 subjects had an adequate response to the vaccine with 7 or more serotypes being higher than 1.3 ?g/mL (>50% response) and were characterized as ?responders?. Subjects with SAD received more antibiotic courses relative to responders in the two years following immunization (3.19 ± 2.64 vs. 2.19 ± 2.24, p<0.05). Ten of 56 subjects (17.9%) with SAD received immunoglobulin (Ig) replacement therapy. Subjects receiving Ig had fewer numbers of protective pneumococcal titers post PPV and had more pneumonia (40.0%) versus subjects with SAD not receiving Ig (10.9%). Conclusions: Of 239 CRS patients with normal IgG levels evaluated for immunodeficiency, 56 (23.4%) had SAD. A majority of patients with SAD may not need Ig replacement however, a subset of patients with SAD benefit from Ig replacement. Twit Text FOAVip Clinical Characteristics of Adults with Chronic Rhinosinusitis and Specific Antibody Deficiency ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=25609325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25609325 #FOAvip English Wikipedia <ref>{{Cite pmid|25609325}}</ref> Clinical Characteristics of Adults with Chronic Rhinosinusitis and Specific Antibody Deficiency #MMPMID25609325 Kashani S; Carr TF; Grammer LC; Schleimer RP; Hulse KE; Kato A; Kern RC; Conley DB; Chandra RK; Tan BK; Peters AT J Allergy Clin Immunol Pract 2015[Mar]; 3 (2): 236-42 PMID25609325show ga Background: Specific antibody deficiency (SAD) involves a deficient response to a polysaccharide vaccine in the setting of normal IgG levels and chronic infections. Patients with chronic rhinosinusitis (CRS) are often evaluated for SAD. There is limited data describing patients with CRS and SAD. Objective: To better characterize the role of SAD in CRS. Methods: We reviewed electronic records of adults with CRS who were evaluated for immunodeficiency with quantitative immunoglobulin levels and pre- and post-antibody titers to a pneumococcal polysaccharide vaccine (PPV). Results: 14 pneumococcal serotypes were determined in 239 subjects from 2002?2009. 64 subjects had adequate protective titers of 1.3 ?g/mL or higher in 7 or more serotypes out of the 14 serotypes checked. 56 (23%) had less than 7 protective titers post-PPV and were diagnosed with SAD. 119 subjects had an adequate response to the vaccine with 7 or more serotypes being higher than 1.3 ?g/mL (>50% response) and were characterized as ?responders?. Subjects with SAD received more antibiotic courses relative to responders in the two years following immunization (3.19 ± 2.64 vs. 2.19 ± 2.24, p<0.05). Ten of 56 subjects (17.9%) with SAD received immunoglobulin (Ig) replacement therapy. Subjects receiving Ig had fewer numbers of protective pneumococcal titers post PPV and had more pneumonia (40.0%) versus subjects with SAD not receiving Ig (10.9%). Conclusions: Of 239 CRS patients with normal IgG levels evaluated for immunodeficiency, 56 (23.4%) had SAD. A majority of patients with SAD may not need Ig replacement however, a subset of patients with SAD benefit from Ig replacement. äClinical Characteristics of Adults with Chronic Rhinosinusitis and Spe(epmc).pdf DeepDyve Pubget Overpricing