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10.6051/j.issn2224-3992.2013.02.343 http://scihub22266oqcxt.onion/10.6051/j.issn2224-3992.2013.02.343 C4391819!4391819!25866707     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gastroenterol+Hepatol+Res 2013 ; 2 (11): 845-53 Nephropedia Template TP {{tp|p=25866707|t=2013. Significance of Mouse Models in Dissecting the Mechanism of Human Eosinophilic Gastrointestinal Diseases (EGID) |pdf=|usr=}}{{25866707}} gab.com Text Significance of Mouse Models in Dissecting the Mechanism of Human Eosinophilic Gastrointestinal Diseases (EGID) JO: J Gastroenterol Hepatol Res http://www.kidney.de/pget.php?&tw=1&pmid=25866707 #FOAvip Evidence suggests that eosinophils play a significant role in promoting several gastrointestinal diseases, and animal models are the significant tools to understand the pathogenesis of eosinophil-associatd inflammatory disorders. The focus of this review is on the significance of mouse models that mimic the characteristics of human eosinophilic gastrointestinal diseases. Eosinophils are the important leukocytes with diverse functions in the gastrointestinal tract, such as excretion of intestinal parasites and promoting the pathogenesis of a numerous allergic gastrointestinal disorders like food allergy, parasitic infection, allergic gastroenteritis, allergic colitis, and eosinophilic esophagitis. Among these gastrointestinal diseases, the eosinophilic esophagitis is the most recently recognized disease and the mouse models are proven to be an effective tool to understand the pathophysiology of disease and to test novel treatment strategies. Based on patients allergic conditions and the gene overexpressed in human EGID, a number of gene overexpressed and allergen-challenged mouse models of gastrointestinal disorders were developed. These models were utilized to explore the mechanism(s) that promotes the eosinophil-mediated gastrointestinal diseases including the role of the eosinophil responsive cytokines and chemokines. Herein, we have provided a detailed overviews of the mouse models of gastrointestinal disorders that mimic the human eosinophilic gastrointestinal diseases and can be utilized as a tool for understanding the diseases pathogenesis and developing novel therapeutic targets. Twit Text FOAVip Significance of Mouse Models in Dissecting the Mechanism of Human Eosinophilic Gastrointestinal Diseases (EGID) ????J Gastroenterol Hepatol Res http://www.kidney.de/pget.php?&tw=1&pmid=25866707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25866707 #FOAvip English Wikipedia <ref>{{Cite pmid|25866707}}</ref> Significance of Mouse Models in Dissecting the Mechanism of Human Eosinophilic Gastrointestinal Diseases (EGID) #MMPMID25866707 Mishra A J Gastroenterol Hepatol Res 2013[]; 2 (11): 845-53 PMID25866707show ga Evidence suggests that eosinophils play a significant role in promoting several gastrointestinal diseases, and animal models are the significant tools to understand the pathogenesis of eosinophil-associatd inflammatory disorders. The focus of this review is on the significance of mouse models that mimic the characteristics of human eosinophilic gastrointestinal diseases. Eosinophils are the important leukocytes with diverse functions in the gastrointestinal tract, such as excretion of intestinal parasites and promoting the pathogenesis of a numerous allergic gastrointestinal disorders like food allergy, parasitic infection, allergic gastroenteritis, allergic colitis, and eosinophilic esophagitis. Among these gastrointestinal diseases, the eosinophilic esophagitis is the most recently recognized disease and the mouse models are proven to be an effective tool to understand the pathophysiology of disease and to test novel treatment strategies. Based on patients allergic conditions and the gene overexpressed in human EGID, a number of gene overexpressed and allergen-challenged mouse models of gastrointestinal disorders were developed. These models were utilized to explore the mechanism(s) that promotes the eosinophil-mediated gastrointestinal diseases including the role of the eosinophil responsive cytokines and chemokines. Herein, we have provided a detailed overviews of the mouse models of gastrointestinal disorders that mimic the human eosinophilic gastrointestinal diseases and can be utilized as a tool for understanding the diseases pathogenesis and developing novel therapeutic targets. äSignificance of Mouse Models in Dissecting the Mechanism of Human Eosi(epmc).pdf DeepDyve Pubget Overpricing