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10.1016/j.celrep.2014.11.035 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.11.035 C4391630!4391630!25497095     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 9 (6): 2180-91 Nephropedia Template TP {{tp|p=25497095|t=2014. Physiological roles for mafr-1 in reproduction and lipid homeostasis |pdf=|usr=}}{{25497095}} gab.com Text Physiological roles for mafr-1 in reproduction and lipid homeostasis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25497095 #FOAvip Maf1 is a conserved repressor of RNA polymerase (pol) III transcription; however, its physiological role in the context of a multicellular organism is not well understood. Here, we show that C. elegans MAFR-1 is functionally orthologous to human Maf1, represses the expression of both RNA pol III and pol II transcripts, and mediates organismal fecundity and lipid homeostasis. MAFR-1 impacts lipid transport by modulating intestinal expression of the vitellogenin family of proteins, resulting in cell non-autonomous defects in the developing reproductive system. MAFR-1 levels inversely correlate with stored intestinal lipids, in part by influencing the expression of the lipogenesis enzymes fasn-1/FASN and pod-2/ACC1. Animals fed a high carbohydrate diet exhibit reduced mafr-1 expression and mutations in the insulin signaling pathway genes daf-18/PTEN and daf-16/FoxO abrogate the lipid storage defects associated with deregulated mafr-1 expression. Our results reveal physiological roles for mafr-1 in regulating organismal lipid homeostasis, which ensure reproductive success. Twit Text FOAVip Physiological roles for mafr-1 in reproduction and lipid homeostasis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25497095 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25497095 #FOAvip English Wikipedia <ref>{{Cite pmid|25497095}}</ref> Physiological roles for mafr-1 in reproduction and lipid homeostasis #MMPMID25497095 Khanna A; Johnson DL; Curran SP Cell Rep 2014[Dec]; 9 (6): 2180-91 PMID25497095show ga Maf1 is a conserved repressor of RNA polymerase (pol) III transcription; however, its physiological role in the context of a multicellular organism is not well understood. Here, we show that C. elegans MAFR-1 is functionally orthologous to human Maf1, represses the expression of both RNA pol III and pol II transcripts, and mediates organismal fecundity and lipid homeostasis. MAFR-1 impacts lipid transport by modulating intestinal expression of the vitellogenin family of proteins, resulting in cell non-autonomous defects in the developing reproductive system. MAFR-1 levels inversely correlate with stored intestinal lipids, in part by influencing the expression of the lipogenesis enzymes fasn-1/FASN and pod-2/ACC1. Animals fed a high carbohydrate diet exhibit reduced mafr-1 expression and mutations in the insulin signaling pathway genes daf-18/PTEN and daf-16/FoxO abrogate the lipid storage defects associated with deregulated mafr-1 expression. Our results reveal physiological roles for mafr-1 in regulating organismal lipid homeostasis, which ensure reproductive success. äPhysiological roles for mafr-1 in reproduction and lipid homeostasis (epmc).pdf DeepDyve Pubget Overpricing