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10.1007/s12079-014-0246-6 http://scihub22266oqcxt.onion/10.1007/s12079-014-0246-6 C4390797!4390797!25278167     free     free     free       J+Cell+Commun+Signal 2014 ; 8 (4): 363-7 Nephropedia Template TP {{tp|p=25278167|t=2014. The fifth dimension of innate immunity |pdf=|usr=}}{{25278167}} gab.com Text The fifth dimension of innate immunity JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25278167 #FOAvip Innate immunity has evolved as a first line defense against invading pathogens. Cellular and humoral elements of the innate immune system detect infectious parasites, initiate inflammatory resistance reactions and finally contribute to the elimination of the invaders. Repeated attacks by pathogenic agents induce adaptive responses of the innate immune system. Typically, reapplication of pathogens provokes tolerance of the affected organism. However, also stimulatory effects of primary infections on subsequent innate immune responses have been observed. The present overview touches an undervalued aspect in the innate immune response: Its pronounced dependency on pathogen load. In addition to localization and timing of innate immune responses the pathogen dose dependency might be considered as a ?fifth dimension of innate immunity?. Experimental results and literature data are presented proposing a hormetic reaction pattern of innate immune cells depending on the dose of pathogens. Twit Text FOAVip The fifth dimension of innate immunity ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25278167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25278167 #FOAvip English Wikipedia <ref>{{Cite pmid|25278167}}</ref> The fifth dimension of innate immunity #MMPMID25278167 Schmidt C; Schneble N; Wetzker R J Cell Commun Signal 2014[Dec]; 8 (4): 363-7 PMID25278167show ga Innate immunity has evolved as a first line defense against invading pathogens. Cellular and humoral elements of the innate immune system detect infectious parasites, initiate inflammatory resistance reactions and finally contribute to the elimination of the invaders. Repeated attacks by pathogenic agents induce adaptive responses of the innate immune system. Typically, reapplication of pathogens provokes tolerance of the affected organism. However, also stimulatory effects of primary infections on subsequent innate immune responses have been observed. The present overview touches an undervalued aspect in the innate immune response: Its pronounced dependency on pathogen load. In addition to localization and timing of innate immune responses the pathogen dose dependency might be considered as a ?fifth dimension of innate immunity?. Experimental results and literature data are presented proposing a hormetic reaction pattern of innate immune cells depending on the dose of pathogens. äThe fifth dimension of innate immunity (epmc).pdf DeepDyve Pubget Overpricing