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10.1007/s12079-014-0248-4 http://scihub22266oqcxt.onion/10.1007/s12079-014-0248-4 C4390794!4390794!25284448     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Commun+Signal 2014 ; 8 (4): 323-31 Nephropedia Template TP {{tp|p=25284448|t=2014. New considerations on hormetic response against oxidative stress |pdf=|usr=}}{{25284448}} gab.com Text New considerations on hormetic response against oxidative stress JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25284448 #FOAvip In order to survive living organisms have developed multiple mechanisms to deal with tough environmental conditions. Hormesis is defined as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism. In this paper, we examine several ideas that might be taken into consideration before using hormesis as a therapeutic tool to improve health and life span, and hopefully will open the discussion for new and interesting debates regard hormesis. The first one is to understand that the same stressor or inductor can activate different pathways in a parallel or dual response, which might lead to diverse outcomes. Another idea is related to the mechanisms involved in activating Nrf2, which might be different and have diverse hormetic effects.Last, we discuss mild oxidative stress in association to low-grade chronic inflammation as a stimulating avenue to be explored and the unexpected effects proposed by the obesity paradox theory. All the previous might help to clarify the reasons why centenarians are able to reach the extreme limits of human life span, which could probably be related to the way they deal with homeostasis maintenance, providing an opportunity for hormesis to intervene significantly. Twit Text FOAVip New considerations on hormetic response against oxidative stress ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25284448 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25284448 #FOAvip English Wikipedia <ref>{{Cite pmid|25284448}}</ref> New considerations on hormetic response against oxidative stress #MMPMID25284448 Luna?López A; González-Puertos VY; López-Diazguerrero NE; Königsberg M J Cell Commun Signal 2014[Dec]; 8 (4): 323-31 PMID25284448show ga In order to survive living organisms have developed multiple mechanisms to deal with tough environmental conditions. Hormesis is defined as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism. In this paper, we examine several ideas that might be taken into consideration before using hormesis as a therapeutic tool to improve health and life span, and hopefully will open the discussion for new and interesting debates regard hormesis. The first one is to understand that the same stressor or inductor can activate different pathways in a parallel or dual response, which might lead to diverse outcomes. Another idea is related to the mechanisms involved in activating Nrf2, which might be different and have diverse hormetic effects.Last, we discuss mild oxidative stress in association to low-grade chronic inflammation as a stimulating avenue to be explored and the unexpected effects proposed by the obesity paradox theory. All the previous might help to clarify the reasons why centenarians are able to reach the extreme limits of human life span, which could probably be related to the way they deal with homeostasis maintenance, providing an opportunity for hormesis to intervene significantly. äNew considerations on hormetic response against oxidative stress (epmc).pdf DeepDyve Pubget Overpricing