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10.1371/journal.pone.0125282 http://scihub22266oqcxt.onion/10.1371/journal.pone.0125282 C4390355!4390355 !25853556     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25853556 &cmd=llinks): Failed to open stream: HTTP request failed! 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Combined biomarker analysis for risk of acute kidney injury in patients with ST-segment elevation myocardial infarction |pdf=|usr=}}{{25853556 }} gab.com Text Combined biomarker analysis for risk of acute kidney injury in patients with ST-segment elevation myocardial infarction JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853556 #FOAvip BACKGROUND: Acute kidney injury (AKI) complicating ST-segment elevation myocardial infarction (STEMI) increases subsequent morbidity and mortality. We combined the biomarkers of heart failure (HF; B-type natriuretic peptide [BNP] and soluble ST2 [sST2]) and renal injury (NGAL [neutrophil gelatinase-associated lipocalin] and cystatin C) in predicting the development of AKI in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: From March 2010 to September 2013, 189 STEMI patients were sequentially enrolled and serum samples were collected at presentation for BNP, sST2, NGAL and cystatin C analysis. 37 patients (19.6%) developed AKI of varying severity within 48 hours of presentation. Univariate analysis showed age, Killip class ?2, hypertension, white blood cell counts, hemoglobin, estimated glomerular filtration rate, blood urea nitrogen, creatinine, and all the four biomarkers were predictive of AKI. Serum levels of the biomarkers were correlated with risk of AKI and the Acute Kidney Injury Network (AKIN) stage and all significantly discriminated AKI (area under the receiver operating characteristic [ROC] curve: BNP: 0.86, sST2: 0.74, NGAL: 0.75, cystatin C: 0.73; all P < 0.05). Elevation of ?2 of the biomarkers higher than the cutoff values derived from the ROC analysis improved AKI risk stratification, regardless of the creatine level (creatinine < 1.24 mg/dL: odds ratio [OR] 11.25, 95% confidence interval [CI] 1.63-77.92, P = 0.014; creatinine ? 1.24: OR 15.0, 95% CI 1.23-183.6, P = 0.034). CONCLUSIONS: In this study of STEMI patients undergoing primary PCI, the biomarkers of heart failure (BNP and sST2) and renal injury (NGAL and cystatin C) at presentation were predictive of AKI. High serum levels of the biomarkers were associated with an elevated risk and more advanced stage of AKI. Regardless of the creatinine level, elevation of ?2 of the biomarkers higher than the cutoff values indicated a further rise in AKI risk. Combined biomarker approach may assist in risk stratification of AKI in patients with STEMI. Twit Text FOAVip Combined biomarker analysis for risk of acute kidney injury in patients with ST-segment elevation myocardial infarction ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25853556 #FOAvip English Wikipedia <ref>{{Cite pmid|25853556 }}</ref> Combined biomarker analysis for risk of acute kidney injury in patients with ST-segment elevation myocardial infarction #MMPMID25853556 Tung YC ; Chang CH ; Chen YC ; Chu PH PLoS One 2015[]; 10 (4 ): e0125282 PMID25853556 show ga BACKGROUND: Acute kidney injury (AKI) complicating ST-segment elevation myocardial infarction (STEMI) increases subsequent morbidity and mortality. We combined the biomarkers of heart failure (HF; B-type natriuretic peptide [BNP] and soluble ST2 [sST2]) and renal injury (NGAL [neutrophil gelatinase-associated lipocalin] and cystatin C) in predicting the development of AKI in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: From March 2010 to September 2013, 189 STEMI patients were sequentially enrolled and serum samples were collected at presentation for BNP, sST2, NGAL and cystatin C analysis. 37 patients (19.6%) developed AKI of varying severity within 48 hours of presentation. Univariate analysis showed age, Killip class ?2, hypertension, white blood cell counts, hemoglobin, estimated glomerular filtration rate, blood urea nitrogen, creatinine, and all the four biomarkers were predictive of AKI. Serum levels of the biomarkers were correlated with risk of AKI and the Acute Kidney Injury Network (AKIN) stage and all significantly discriminated AKI (area under the receiver operating characteristic [ROC] curve: BNP: 0.86, sST2: 0.74, NGAL: 0.75, cystatin C: 0.73; all P < 0.05). Elevation of ?2 of the biomarkers higher than the cutoff values derived from the ROC analysis improved AKI risk stratification, regardless of the creatine level (creatinine < 1.24 mg/dL: odds ratio [OR] 11.25, 95% confidence interval [CI] 1.63-77.92, P = 0.014; creatinine ? 1.24: OR 15.0, 95% CI 1.23-183.6, P = 0.034). CONCLUSIONS: In this study of STEMI patients undergoing primary PCI, the biomarkers of heart failure (BNP and sST2) and renal injury (NGAL and cystatin C) at presentation were predictive of AKI. High serum levels of the biomarkers were associated with an elevated risk and more advanced stage of AKI. Regardless of the creatinine level, elevation of ?2 of the biomarkers higher than the cutoff values indicated a further rise in AKI risk. Combined biomarker approach may assist in risk stratification of AKI in patients with STEMI. |Acute Kidney Injury/diagnosis/*epidemiology/*pathology [MESH] |Acute-Phase Proteins [MESH] |Aged [MESH] |Biomarkers/*blood [MESH] |Cystatin C/blood [MESH] |Female [MESH] |Heart Failure/complications/*pathology [MESH] |Humans [MESH] |Interleukin-1 Receptor-Like 1 Protein [MESH] |Lipocalin-2 [MESH] |Lipocalins/blood [MESH] |Male [MESH] |Middle Aged [MESH] |Myocardial Infarction/complications/*pathology [MESH] |Natriuretic Peptide, Brain/blood [MESH] |Proto-Oncogene Proteins/blood [MESH] |ROC Curve [MESH]Combined biomarker analysis for risk of acute kidney injury in patient(epmc).pdf DeepDyve Pubget Overpricing