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10.1371/journal.pone.0122656 http://scihub22266oqcxt.onion/10.1371/journal.pone.0122656 C4390222!4390222 !25853697     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25853697 &cmd=llinks): Failed to open stream: HTTP request failed! 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Endobronchial coils for severe emphysema are effective up to 12 months following treatment: medium term and cross-over results from a randomised controlled trial |pdf=|usr=}}{{25853697 }} gab.com Text Endobronchial coils for severe emphysema are effective up to 12 months following treatment: medium term and cross-over results from a randomised controlled trial JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853697 #FOAvip BACKGROUND: There is a clinical need for therapeutic options to reduce hyperinflation associated with severe emphysema. Endobronchial Coils (coils) are nitinol devices implanted bronchoscopically under fluoroscopic guidance to re-tension the lung. We report the medium term effectiveness and safety of coils in a study of patients with emphysema. METHODS: Forty five subjects with severe airflow obstruction and hyperinflation received bilateral sequential treatment with coils (30 day interval between treatments) as part of a randomised controlled trial with a primary endpoint 90 days after the final treatment (Clinicaltrials.gov NCT01334307). Further assessments were made at 180 and 360 days and in this study the primary outcome was the effect of coil treatment on the St. George's Respiratory Questionnaire (SGRQ) 360 days following treatment. RESULTS: At 360 days following treatment, there was an improvement in the SGRQ score of -6.1±14.0 points (p = 0.01) compared to baseline. Improvements in secondary outcomes were seen with increases in forced expiratory volume in the first second of 8.9 ±22.2% (p = 0.002) and 6-minute walking distance of 34.1±52.4m (p = 0.003). The safety profile was acceptable out to 360 days post-treatment. CONCLUSIONS: Statistically and clinically meaningful benefits in quality of life, exercise capacity and pulmonary function in patients treated with coils are sustained twelve months after treatment. TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov NCT01334307. Twit Text FOAVip Endobronchial coils for severe emphysema are effective up to 12 months following treatment: medium term and cross-over results from a randomised controlled trial ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25853697 #FOAvip English Wikipedia <ref>{{Cite pmid|25853697 }}</ref> Endobronchial coils for severe emphysema are effective up to 12 months following treatment: medium term and cross-over results from a randomised controlled trial #MMPMID25853697 Zoumot Z ; Kemp SV ; Singh S ; Bicknell SR ; McNulty WH ; Hopkinson NS ; Ross ET ; Shah PL PLoS One 2015[]; 10 (4 ): e0122656 PMID25853697 show ga BACKGROUND: There is a clinical need for therapeutic options to reduce hyperinflation associated with severe emphysema. Endobronchial Coils (coils) are nitinol devices implanted bronchoscopically under fluoroscopic guidance to re-tension the lung. We report the medium term effectiveness and safety of coils in a study of patients with emphysema. METHODS: Forty five subjects with severe airflow obstruction and hyperinflation received bilateral sequential treatment with coils (30 day interval between treatments) as part of a randomised controlled trial with a primary endpoint 90 days after the final treatment (Clinicaltrials.gov NCT01334307). Further assessments were made at 180 and 360 days and in this study the primary outcome was the effect of coil treatment on the St. George's Respiratory Questionnaire (SGRQ) 360 days following treatment. RESULTS: At 360 days following treatment, there was an improvement in the SGRQ score of -6.1±14.0 points (p = 0.01) compared to baseline. Improvements in secondary outcomes were seen with increases in forced expiratory volume in the first second of 8.9 ±22.2% (p = 0.002) and 6-minute walking distance of 34.1±52.4m (p = 0.003). The safety profile was acceptable out to 360 days post-treatment. CONCLUSIONS: Statistically and clinically meaningful benefits in quality of life, exercise capacity and pulmonary function in patients treated with coils are sustained twelve months after treatment. TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov NCT01334307. |*Bronchoscopy [MESH] |*Prostheses and Implants [MESH] |Adult [MESH] |Aged [MESH] |Female [MESH] |Forced Expiratory Volume [MESH] |Humans [MESH] |Lung/*physiopathology [MESH] |Male [MESH] |Middle Aged [MESH] |Pulmonary Emphysema/physiopathology/*therapy [MESH] |Surveys and Questionnaires [MESH]Endobronchial coils for severe emphysema are effective up to 12 months(epmc).pdf DeepDyve Pubget Overpricing