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10.1371/journal.pone.0125176 http://scihub22266oqcxt.onion/10.1371/journal.pone.0125176 C4390193!4390193 !25853493     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25853493 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25853493 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (4 ): e0125176 Nephropedia Template TP {{tp|p=25853493 |t=2015. Protective role of PGC-1? in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling |pdf=|usr=}}{{25853493 }} gab.com Text Protective role of PGC-1 in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853493 #FOAvip The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1? in the pathogenesis of DN. Rat glomerular mesangial cells (RMCs) were incubated in normal or high glucose medium with or without the PGC-1?-overexpressing plasmid (pcDNA3-PGC-1?) for 48 h. In the diabetic rats, decreased PGC-1? expression was associated with increased mitochondrial ROS generation in the renal cortex, increased proteinuria, glomerular hypertrophy, and higher glomerular 8-OHdG (a biomarker for oxidative stress). In vitro, hyperglycemia induced the downregulation of PGC-1?, which led to increased DRP1 expression, increased mitochondrial fragmentation and damaged network structure. This was associated with an increase in ROS generation and mesangial cell hypertrophy. These pathological changes were reversed in vitro by the transfection of pcDNA3-PGC-1?. These data suggest that PGC-1? may protect DN via the inhibition of DRP1-mediated mitochondrial dynamic remodeling and ROS production. These findings may assist the development of novel therapeutic strategies for patients with DN. Twit Text FOAVip Protective role of PGC-1 in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25853493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25853493 #FOAvip English Wikipedia <ref>{{Cite pmid|25853493 }}</ref> Protective role of PGC-1? in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling #MMPMID25853493 Guo K ; Lu J ; Huang Y ; Wu M ; Zhang L ; Yu H ; Zhang M ; Bao Y ; He JC ; Chen H ; Jia W PLoS One 2015[]; 10 (4 ): e0125176 PMID25853493 show ga The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1? in the pathogenesis of DN. Rat glomerular mesangial cells (RMCs) were incubated in normal or high glucose medium with or without the PGC-1?-overexpressing plasmid (pcDNA3-PGC-1?) for 48 h. In the diabetic rats, decreased PGC-1? expression was associated with increased mitochondrial ROS generation in the renal cortex, increased proteinuria, glomerular hypertrophy, and higher glomerular 8-OHdG (a biomarker for oxidative stress). In vitro, hyperglycemia induced the downregulation of PGC-1?, which led to increased DRP1 expression, increased mitochondrial fragmentation and damaged network structure. This was associated with an increase in ROS generation and mesangial cell hypertrophy. These pathological changes were reversed in vitro by the transfection of pcDNA3-PGC-1?. These data suggest that PGC-1? may protect DN via the inhibition of DRP1-mediated mitochondrial dynamic remodeling and ROS production. These findings may assist the development of novel therapeutic strategies for patients with DN. |8-Hydroxy-2'-Deoxyguanosine [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Deoxyguanosine/analogs & derivatives/metabolism [MESH] |Diabetic Nephropathies/genetics/*metabolism/pathology [MESH] |Dynamins/*genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |Glucose/metabolism/pharmacology [MESH] |Humans [MESH] |Hyperglycemia/genetics/*metabolism/pathology [MESH] |Male [MESH] |Mesangial Cells/drug effects/metabolism/pathology [MESH] |Mitochondria/drug effects/metabolism/pathology [MESH] |Mitochondrial Dynamics/drug effects/*genetics [MESH] |Oxidative Stress [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [MESH] |Plasmids/chemistry/metabolism [MESH] |Primary Cell Culture [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Reactive Oxygen Species/*antagonists & inhibitors/metabolism [MESH] |Signal Transduction [MESH] |Transcription Factors/*genetics/metabolism [MESH]Protective role of PGC-1? in diabetic nephropathy is associated with t(epmc).pdf DeepDyve Pubget Overpricing