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10.1016/j.cell.2014.11.035 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.11.035 C4390143!4390143!25525873     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25525873&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 159 (7): 1511-23 Nephropedia Template TP {{tp|p=25525873|t=2014. A highly conserved program of neuronal microexons is misregulated in autistic brains |pdf=|usr=}}{{25525873}} gab.com Text A highly conserved program of neuronal microexons is misregulated in autistic brains JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25525873 #FOAvip Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events provide important biological functions is not well understood. Here, we define the largest program of functionally coordinated, neural-regulated AS described to date in mammals. Relative to all other types of AS within this program, 3-15 nucleotide ?microexons? display the most striking evolutionary conservation and switch-like regulation. These microexons modulate the function of interaction domains of proteins involved in neurogenesis. Most neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs. Neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. The results thus reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein interaction networks during neurogenesis, the misregulation of which is linked to autism. Twit Text FOAVip A highly conserved program of neuronal microexons is misregulated in autistic brains ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25525873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25525873 #FOAvip English Wikipedia <ref>{{Cite pmid|25525873}}</ref> A highly conserved program of neuronal microexons is misregulated in autistic brains #MMPMID25525873 Irimia M; Weatheritt RJ; Ellis J; Parikshak NN; Gonatopoulos-Pournatzis T; Babor M; Quesnel-Vallières M; Tapial J; Raj B; O?Hanlon D; Barrios-Rodiles M; Sternberg MJ; Cordes SP; Roth FP; Wrana JL; Geschwind DH; Blencowe BJ Cell 2014[Dec]; 159 (7): 1511-23 PMID25525873show ga Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events provide important biological functions is not well understood. Here, we define the largest program of functionally coordinated, neural-regulated AS described to date in mammals. Relative to all other types of AS within this program, 3-15 nucleotide ?microexons? display the most striking evolutionary conservation and switch-like regulation. These microexons modulate the function of interaction domains of proteins involved in neurogenesis. Most neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs. Neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. The results thus reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein interaction networks during neurogenesis, the misregulation of which is linked to autism. äA highly conserved program of neuronal microexons is misregulated in a(epmc).pdf DeepDyve Pubget Overpricing