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10.1002/wrna.1266 http://scihub22266oqcxt.onion/10.1002/wrna.1266 C4390053!4390053!25363811     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Wiley+Interdiscip+Rev+RNA 2015 ; 6 (2): 173-89 Nephropedia Template TP {{tp|p=25363811|t=2015. Small RNAs with big implications: New insights into H/ACA snoRNA function and their role in human disease |pdf=|usr=}}{{25363811}} gab.com Text Small RNAs with big implications: New insights into H/ACA snoRNA function and their role in human disease JO: Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=25363811 #FOAvip A myriad of structurally and functionally diverse non-coding RNAs (ncRNAs) have recently been implicated in numerous human diseases including cancer. Small nucleolar RNAs (snoRNAs), the most abundant group of intron-encoded ncRNAs, are classified into two families (box C/D snoRNAs and box H/ACA snoRNAs) and are required for post-transcriptional modifications of ribosomal RNA (rRNA). There is now a growing appreciation that nucleotide modifications on rRNA may impart regulatory potential to the ribosome, however the functional consequence of site-specific snoRNA-guided modifications remains poorly defined. Discovered almost 20 years ago, H/ACA snoRNAs are required for the conversion of specific uridine residues to pseudouridine on rRNA. Interestingly, recent reports indicate that the levels of subsets of H/ACA snoRNAs required for pseudouridine modifications at specific sites on rRNA are altered in several diseases, particularly cancer. In this review, we describe recent advances in understanding the downstream consequences of H/ACA snoRNA-guided modifications on ribosome function, discuss the possible mechanism by which H/ACA snoRNAs may be regulated, and explore prospective expanding functions of H/ACA snoRNAs. Furthermore, we will discuss the potential biological implication of alterations in H/ACA snoRNA expression in several human diseases. Twit Text FOAVip Small RNAs with big implications: New insights into H/ACA snoRNA function and their role in human disease ????Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=25363811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25363811 #FOAvip English Wikipedia <ref>{{Cite pmid|25363811}}</ref> Small RNAs with big implications: New insights into H/ACA snoRNA function and their role in human disease #MMPMID25363811 McMahon M; Contreras A; Ruggero D Wiley Interdiscip Rev RNA 2015[Mar]; 6 (2): 173-89 PMID25363811show ga A myriad of structurally and functionally diverse non-coding RNAs (ncRNAs) have recently been implicated in numerous human diseases including cancer. Small nucleolar RNAs (snoRNAs), the most abundant group of intron-encoded ncRNAs, are classified into two families (box C/D snoRNAs and box H/ACA snoRNAs) and are required for post-transcriptional modifications of ribosomal RNA (rRNA). There is now a growing appreciation that nucleotide modifications on rRNA may impart regulatory potential to the ribosome, however the functional consequence of site-specific snoRNA-guided modifications remains poorly defined. Discovered almost 20 years ago, H/ACA snoRNAs are required for the conversion of specific uridine residues to pseudouridine on rRNA. Interestingly, recent reports indicate that the levels of subsets of H/ACA snoRNAs required for pseudouridine modifications at specific sites on rRNA are altered in several diseases, particularly cancer. In this review, we describe recent advances in understanding the downstream consequences of H/ACA snoRNA-guided modifications on ribosome function, discuss the possible mechanism by which H/ACA snoRNAs may be regulated, and explore prospective expanding functions of H/ACA snoRNAs. Furthermore, we will discuss the potential biological implication of alterations in H/ACA snoRNA expression in several human diseases. äSmall RNAs with big implications: New insights into H/ACA snoRNA funct(epmc).pdf DeepDyve Pubget Overpricing