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10.1126/scisignal.2003477 http://scihub22266oqcxt.onion/10.1126/scisignal.2003477 C4390046!4390046!22969157     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2012 ; 5 (241): pe38 Nephropedia Template TP {{tp|p=22969157|t=2012. Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling |pdf=|usr=}}{{22969157}} gab.com Text Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=22969157 #FOAvip Key signaling pathways (such as phosphoinositide 3-kinase, Myc, and RAS) act as sensors of energy, stress, and nutrient availability and integrate these inputs to directly control ribosomeproduction and gene expression at the translational level. This activity is normally directly coupled to cell growth, division, and survival. However, it remains poorly understood the extent to which changes in ribosome number and nucleolar integrity downstream of these key signaling pathways contribute to their oncogenic activity. Emerging studies provide interesting insight into how deregulations in RNA polymerase I activity may lead to tumorigenesis and suggest that new drugs targeting ribosomal DNA transcription may hold great promise for the treatment of cancer. Twit Text FOAVip Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=22969157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22969157 #FOAvip English Wikipedia <ref>{{Cite pmid|22969157}}</ref> Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling #MMPMID22969157 Ruggero D Sci Signal 2012[]; 5 (241): pe38 PMID22969157show ga Key signaling pathways (such as phosphoinositide 3-kinase, Myc, and RAS) act as sensors of energy, stress, and nutrient availability and integrate these inputs to directly control ribosomeproduction and gene expression at the translational level. This activity is normally directly coupled to cell growth, division, and survival. However, it remains poorly understood the extent to which changes in ribosome number and nucleolar integrity downstream of these key signaling pathways contribute to their oncogenic activity. Emerging studies provide interesting insight into how deregulations in RNA polymerase I activity may lead to tumorigenesis and suggest that new drugs targeting ribosomal DNA transcription may hold great promise for the treatment of cancer. äRevisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer (epmc).pdf DeepDyve Pubget Overpricing