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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Assist+Reprod+Genet 2014 ; 31 (11): 1461-7 Nephropedia Template TP
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Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters #MMPMID25205205
Hattori H; Nakamura Y; Nakajo Y; Araki Y; Kyono K
J Assist Reprod Genet 2014[Nov]; 31 (11): 1461-7 PMID25205205show ga
Purpose: To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes. Methods: Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(?) group) in 2,158 patients (3,758 cycles) after ICSI. Results: Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(?) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations. Conclusion(s): The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(?) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.