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suck abstract from ncbi


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      J+Assist+Reprod+Genet 2014 ; 31 (11 ): 1461-7
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  • Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters #MMPMID25205205
  • Hattori H ; Nakamura Y ; Nakajo Y ; Araki Y ; Kyono K
  • J Assist Reprod Genet 2014[Nov]; 31 (11 ): 1461-7 PMID25205205 show ga
  • PURPOSE: To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes. METHODS: Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(-) group) in 2,158 patients (3,758 cycles) after ICSI. RESULTS: Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(-) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations. CONCLUSION(S): The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(-) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.
  • |*Pregnancy Outcome [MESH]
  • |Adult [MESH]
  • |Congenital Abnormalities/epidemiology [MESH]
  • |Embryo Implantation [MESH]
  • |Endoplasmic Reticulum, Smooth/*ultrastructure [MESH]
  • |Female [MESH]
  • |Fertilization [MESH]
  • |Fetal Development [MESH]
  • |Humans [MESH]
  • |Live Birth/epidemiology [MESH]
  • |Oocytes/*ultrastructure [MESH]
  • |Pregnancy [MESH]
  • |Retrospective Studies [MESH]


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