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2014 ; 31
(11
): 1461-7
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Deliveries of babies with normal health derived from oocytes with smooth
endoplasmic reticulum clusters
#MMPMID25205205
Hattori H
; Nakamura Y
; Nakajo Y
; Araki Y
; Kyono K
J Assist Reprod Genet
2014[Nov]; 31
(11
): 1461-7
PMID25205205
show ga
PURPOSE: To examine the impact on development of derived embryos from smooth
endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.
METHODS: Retrospective analysis at Kyono ART Clinic. Comparison of embryological
development, pregnancy, live birth and fetal malformation between oocytes with
SERC (the SERC(+) group) and those without (the SERC(-) group) in 2,158 patients
(3,758 cycles) after ICSI. RESULTS: Fertilization and implantation rate were
significantly lower in SERC(+) MII oocytes than in SERC(-) MII oocytes. After the
transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14
pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer
(ET) and 12 from vitrified-warmed ET, with no malformations. CONCLUSION(S): The
presence of SERC in MII oocytes was associated with significantly lower
fertilization rates and implantation rates than seen in SERC(-) MII oocytes
within SERC (+) cycles. However, SERC had no impact on post-implantation
development as well as neonatal outcome.