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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Assist+Reprod+Genet 2014 ; 31 (11): 1553-5 Nephropedia Template TP
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Successful live birth from oocytes after more than 14 years of cryopreservation #MMPMID25205204
J Assist Reprod Genet 2014[Nov]; 31 (11): 1553-5 PMID25205204show ga
Objective: To report a birth of a healthy girl after long-term oocyte cryopreservation by slow cooling in sodium depleted medium. Design: Clinical application. Setting: University Affiliated, Private IVF center. Patient: A 38-year-old woman received embryos from IVF by intracytoplasmic sperm injection (ICSI) with her own oocytes that were cryopreserved by slow freezing in a low-sodium medium 14 years and 6 months before, when she was 24 years old. Main outcome measure(s): Survival, fertilization, cleavage, clinical pregnancy and delivery. Result(s): From six metaphase-II oocytes thawed, two survived, one was fertilized after ICSI and a cleaving embryo was transferred on day 3. A single term pregnancy was achieved, ending with the delivery of a healthy girl. Conclusion(s): Cryopreservation after slow freezing in a sodium depleted medium maintained the developmental competence of oocytes after long-term storage and resulted in a successful live birth. As far as is known, this case represents, up to date, the longest storage period of cryopreserved human oocytes resulting in a live birth.