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10.1186/s13045-015-0127-3 http://scihub22266oqcxt.onion/10.1186/s13045-015-0127-3 C4389696!4389696!25888285     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hematol+Oncol 2015 ; 8 (ä): ä Nephropedia Template TP {{tp|p=25888285|t=2015. RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes |pdf=|usr=}}{{25888285}} gab.com Text RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25888285 #FOAvip From its discovery as an adaptive bacterial and archaea immune system, the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system has quickly been developed into a powerful and groundbreaking programmable nuclease technology for the global and precise editing of the genome in cells. This system allows for comprehensive unbiased functional studies and is already advancing the field by revealing genes that have previously unknown roles in disease processes. In this review, we examine and compare recently developed CRISPR-Cas platforms for global genome editing and examine the advancements these platforms have made in guide RNA design, guide RNA/Cas9 interaction, on-target specificity, and target sequence selection. We also explore some of the exciting therapeutic potentials of the CRISPR-Cas technology as well as some of the innovative new uses of this technology beyond genome editing. Twit Text FOAVip RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25888285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25888285 #FOAvip English Wikipedia <ref>{{Cite pmid|25888285}}</ref> RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes #MMPMID25888285 Humphrey SE; Kasinski AL J Hematol Oncol 2015[]; 8 (ä): ä PMID25888285show ga From its discovery as an adaptive bacterial and archaea immune system, the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system has quickly been developed into a powerful and groundbreaking programmable nuclease technology for the global and precise editing of the genome in cells. This system allows for comprehensive unbiased functional studies and is already advancing the field by revealing genes that have previously unknown roles in disease processes. In this review, we examine and compare recently developed CRISPR-Cas platforms for global genome editing and examine the advancements these platforms have made in guide RNA design, guide RNA/Cas9 interaction, on-target specificity, and target sequence selection. We also explore some of the exciting therapeutic potentials of the CRISPR-Cas technology as well as some of the innovative new uses of this technology beyond genome editing. äRNA-guided CRISPR-Cas technologies for genome-scale investigation of d(epmc).pdf DeepDyve Pubget Overpricing