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10.1038/ncomms7673 http://scihub22266oqcxt.onion/10.1038/ncomms7673 C4389265!4389265 !25809117     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25809117 &cmd=llinks): Failed to open stream: HTTP request failed! 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Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature |pdf=|usr=}}{{25809117 }} gab.com Text Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25809117 #FOAvip Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream infection with methicillin-resistant Staphylococcus aureus, the majority of bacteria are sequestered immediately by hepatic Kupffer cells, resulting in transient increases in liver enzymes, focal ischaemic areas and a robust neutrophil infiltration into the liver. The neutrophils release NETs into the liver vasculature, which remain anchored to the vascular wall via von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity. Importantly, DNase although very effective at DNA removal, and somewhat effective at inhibiting NE proteolytic activity, fails to remove the majority of histones from the vessel wall and only partly reduces injury. By contrast, inhibition of NET production as modelled by PAD4-deficiency, or prevention of NET formation and proteolytic activity as modelled in NE(-/-) mice prevent collateral host tissue damage. Twit Text FOAVip Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25809117 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25809117 #FOAvip English Wikipedia <ref>{{Cite pmid|25809117 }}</ref> Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature #MMPMID25809117 Kolaczkowska E ; Jenne CN ; Surewaard BG ; Thanabalasuriar A ; Lee WY ; Sanz MJ ; Mowen K ; Opdenakker G ; Kubes P Nat Commun 2015[Mar]; 6 (ä): 6673 PMID25809117 show ga Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream infection with methicillin-resistant Staphylococcus aureus, the majority of bacteria are sequestered immediately by hepatic Kupffer cells, resulting in transient increases in liver enzymes, focal ischaemic areas and a robust neutrophil infiltration into the liver. The neutrophils release NETs into the liver vasculature, which remain anchored to the vascular wall via von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity. Importantly, DNase although very effective at DNA removal, and somewhat effective at inhibiting NE proteolytic activity, fails to remove the majority of histones from the vessel wall and only partly reduces injury. By contrast, inhibition of NET production as modelled by PAD4-deficiency, or prevention of NET formation and proteolytic activity as modelled in NE(-/-) mice prevent collateral host tissue damage. |Animals [MESH] |Bacteremia/*immunology/metabolism [MESH] |Deoxyribonucleases/metabolism [MESH] |Extracellular Traps/*immunology [MESH] |Hepatic Artery/*immunology/metabolism [MESH] |Hepatic Veins/*immunology/metabolism [MESH] |Histones/metabolism [MESH] |Hydrolases/genetics [MESH] |Kupffer Cells/immunology [MESH] |Leukocyte Elastase/*genetics/metabolism [MESH] |Liver/blood supply/enzymology/*immunology/metabolism [MESH] |Male [MESH] |Methicillin-Resistant Staphylococcus aureus [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neutrophil Infiltration [MESH] |Protein-Arginine Deiminase Type 4 [MESH] |Staphylococcal Infections/*immunology/metabolism [MESH]Molecular mechanisms of NET formation and degradation revealed by intr(epmc).pdf DeepDyve Pubget Overpricing